Ruthenium-catalyzed oxidative alkyne annulation by C-H activation on ketimines

被引：34
|
作者：
Li, Jie [1 ]
Ackermann, Lutz [1 ]
机构：
[1] Univ Gottingen, Inst Organ & Biomol Chem, D-37077 Gottingen, Germany
来源：
TETRAHEDRON | 2014年 / 70卷 / 20期
基金：
欧洲研究理事会;
关键词：
C-H activation; Isoquinolines; Heterocycles; Ketimines; Multicatalysis; Ruthenium; ONE-POT SYNTHESIS; N BOND FORMATION; ISOQUINOLINIUM SALTS; FUNCTIONALIZATION; PYRIDINES; CYCLIZATION; PALLADIUM; KETOXIMES; IMINES; RH;
D O I：
10.1016/j.tet.2013.10.003
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Carboxylate assistance allowed for ruthenium(II)-catalyzed oxidative alkyne annulations by ketimines under an ambient atmosphere of air. The ruthenium catalyst outperformed representative rhodium and palladium complexes, and provided versatile access to differently decorated 1-methylene-1,2-dihydroisoquinolines in a highly step- and atom-economical manner. Detailed mechanistic studies provided evidence for an initial reversible C-H bond activation event. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3342 / 3348
页数：7
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