Ruthenium-catalyzed oxidative alkyne annulation by C-H activation on ketimines

被引：34

作者：

Li, Jie ^{[1
]}

Ackermann, Lutz ^{[1
]}

机构：

[1] Univ Gottingen, Inst Organ & Biomol Chem, D-37077 Gottingen, Germany

来源：

TETRAHEDRON | 2014年 / 70卷 / 20期

基金：

欧洲研究理事会;

关键词：

C-H activation; Isoquinolines; Heterocycles; Ketimines; Multicatalysis; Ruthenium; ONE-POT SYNTHESIS; N BOND FORMATION; ISOQUINOLINIUM SALTS; FUNCTIONALIZATION; PYRIDINES; CYCLIZATION; PALLADIUM; KETOXIMES; IMINES; RH;

D O I：

10.1016/j.tet.2013.10.003

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Carboxylate assistance allowed for ruthenium(II)-catalyzed oxidative alkyne annulations by ketimines under an ambient atmosphere of air. The ruthenium catalyst outperformed representative rhodium and palladium complexes, and provided versatile access to differently decorated 1-methylene-1,2-dihydroisoquinolines in a highly step- and atom-economical manner. Detailed mechanistic studies provided evidence for an initial reversible C-H bond activation event. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：3342 / 3348

页数：7

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