Fabrication of PLA/MWCNT/Fe3O4 composite nanofibers for leukemia cancer cells

被引：45
作者：
Hosseini, Layla [1 ]
Mahboobnia, Khadijeh [2 ]
Irani, Mohammad [3 ]
机构：
[1] Tarbiat Modares Univ, Dept Chem Engn, Biomed Engn Grp, Tehran, Iran
[2] Isfahan Univ Med Sci, Sch Pharm & Pharmaceut Sci, Dept Clin Biochem, Esfahan, Iran
[3] Amirkabir Univ Technol, Tehran Polytech, Dept Chem Engn, Tehran, Iran
来源：
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2016年 / 65卷 / 04期
基金：
美国国家科学基金会;
关键词：
Daunorubicin; leukemia; magnetic field; nanofibers; PLA/MWCNT/Fe3O4; ANTITUMOR-ACTIVITY; CARBON NANOTUBES; DRUG-DELIVERY; MAGNETIC NANOPARTICLES; QUATERNIZED CHITOSAN; CONTROLLED-RELEASE; DOXORUBICIN; NANOCOMPOSITE; POLYLACTIDE; OXIDE;
D O I：
10.1080/00914037.2015.1074912
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
The efficient delivery of daunorubicin loaded poly (lactic acid) (PLA)/multiwalled carbon nanotubes (MWCNT)/Fe3O4 composite nanofibers was investigated. The synthesized nanofibers were characterized using SEM, TEM, and XRD analysis. The proliferation inhibition effect of PLA/MWCNT/Fe3O4 nanofibrous scaffolds on leukemia K562 cell lines was investigated. The effect of nanofiber concentration on the daunorubicin delivery in the absence and presence of external magnetic field was also evaluated. The results indicated that the incorporation of daunorubicin into the prepared nanofibrous scaffold under applied magnetic field could have synergistic cytotoxic effect on leukemia cancer cells. The drug release mechanism followed the non-Fickian transport.
引用
收藏
页码：176 / 182
页数：7
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