Antimicrobial Activities against Periodontopathic Bacteria of Pittosporum tobira and Its Active Compound

被引：12

作者：

Oh, Jung-Hyun ^{[1
,3
]}

Jeong, Yong Joon ^{[2
]}

Koo, Hyun Jung ^{[2
]}

Park, Dae Won ^{[2
]}

Kang, Se Chan ^{[2
]}

Hoang Viet Bach Khoa ^{[4
]}

Le Ba Le ^{[4
]}

Cho, Joon Hyeong ^{[4
]}

Lee, Jin-Yong ^{[1
,3
]}

机构：

[1] Kyung Hee Univ, Sch Dent, Dept Maxillofacial Biomed Engn, Seoul 130701, South Korea

[2] Gachon Univ, Dept Life Sci, Songnam 461701, Gyeonggi Do, South Korea

[3] Kyung Hee Univ, Inst Oral Biol, Seoul 130701, South Korea

[4] Dongguk Univ, Dept Biol & Environm Sci, Seoul 100715, South Korea

来源：

MOLECULES | 2014年 / 19卷 / 03期

基金：

新加坡国家研究基金会;

关键词：

periodonititis; Pittosporium tobira; natural products; R1-barrigenol; triterpene sapogenin; PORPHYROMONAS-GINGIVALIS; ANTIBACTERIAL ACTIVITY; PREVOTELLA-INTERMEDIA; ANTIBIOTIC-RESISTANCE; MEDICINAL-PLANTS; INFECTIONS; PATHOGENS; PERIODONTITIS; DISEASES; STRAINS;

D O I：

10.3390/molecules19033607

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The study of medicinal plants for treatment of periodontitis is of great value to establish their efficacy as sources of new antimicrobial drugs. Five hundred and fifty eight Korean local plant extracts were screened for antibacterial activity against representative periodontopathic bacteria such as Porphyromonas gingivalis, Prevotella intermedia, and Fusobacterium nucleatum. Among the various medicinal plants, the alcohol extract of Pittosporum tobira, which significantly exhibited antibacterial effect for all tested strains, showed the highest activity in the antimicrobial assays. NMR analyses revealed that R1-barrigenol, a triterpene sapogenin, was the most effective compound in P. tobira. These results demonstrated that P. tobira possesses antimicrobial properties and would be beneficial for the prevention and treatment of periodontitis.

引用

页码：3607 / 3616

页数：10

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