Copper(II) triflate-catalyzed reactions for the synthesis of novel and diverse quinoline carboxylates

被引：18

作者：

Pandit, Rameshwar Prasad ^{[1
]}

Lee, Yong Rok ^{[1
]}

机构：

[1] Yeungnam Univ, Sch Chem Engn, Gyongsan 712749, South Korea

来源：

RSC ADVANCES | 2013年 / 3卷 / 44期

基金：

新加坡国家研究基金会;

关键词：

FRIEDLANDER SYNTHESIS; POLYSUBSTITUTED QUINOLINES; EFFICIENT SYNTHESIS; MECHANISM; CYCLIZATION; SKRAUP; ACID; INHIBITORS; METAL;

D O I：

10.1039/c3ra44943b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient one-pot synthesis of a variety of quinoline carboxylates was accomplished by Cu(OTf)(2)-catalyzed reactions of Michael addition/cyclization/aromatization between 2-aminoaryl carbonyls and alkynyl carboxylates. This methodology offers several significant advantages, namely, ease of handling, mild reaction conditions, enhanced reaction rates, and use of an effective and non-toxic catalyst. The synthesized compounds were further transformed into highly functionalized novel quinoline carboxylates bearing aromatic rings on the quinoline skeleton using the Suzuki reaction.

引用

页码：22039 / 22045

页数：7

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