Solution blowing of chitosan/PVA hydrogel nanofiber mats

被引：147
作者：
Liu, Ruifang [1 ]
Xu, Xianlin [1 ,2 ]
Zhuang, Xupin [1 ,2 ]
Cheng, Bowen [1 ,2 ]
机构：
[1] Tianjin Polytech Univ, Coll Text, Tianjin 300387, Peoples R China
[2] Tianjin Polytech Univ, Minist Educ, Key Lab Adv Text Composite Mat, Tianjin 300387, Peoples R China
来源：
CARBOHYDRATE POLYMERS | 2014年 / 101卷
基金：
中国国家自然科学基金;
关键词：
Nanofibers; Hydrogel; Dressing; Chitosan; Solution bolwing; POLY(VINYL ALCOHOL); ADSORPTION; MEMBRANE; PROPERTY; ALGINATE;
D O I：
10.1016/j.carbpol.2013.10.056
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Both nanofiber mats and hydrogel have their own advantages in wound healing. In this study, a novel hydrogel nanofiber mats were fabricated via solution blowing of chitosan and PVA solution, with various content of ethylene glycol diglycidyl ether (EGDE) as cross-linker. SEM observation showed that the fibers were several hundred nanometers in diameter with smooth surface and distributed randomly forming three-dimensional mats. The structure of the chitosan/PVA nanofibers was examined by FTIR and XPS, and the results showed that the cross-linking reaction occurred between EGDE and the hydroxyl groups. The mats could quickly hydrate in an aqueous environment to form hydrogel. Their value of equilibrate water absorption varied from 680 to 459% various content of EGDE. The nanofiber mats showed good bactericidal activity against Escherichia coli. The chitosan/PVA hydrogel nanofiber mats showed the combination advantages of nanofibrous mats and hydrogel dressing, and were suggested as potential application in wound healing. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1116 / 1121
页数：6
相关论文
共 38 条
[1]   Chitosan stabilizes platelet growth factors and modulates stem cell differentiation toward tissue regeneration [J].
Busilacchi, Alberto ;
Gigante, Antonio ;
Mattioli-Belmonte, Monica ;
Manzotti, Sandra ;
Muzzarelli, Riccardo A. A. .
CARBOHYDRATE POLYMERS, 2013, 98 (01) :665-676
[2]   Fabrication of Chitosan/Silk Fibroin Composite Nanofibers for Wound-dressing Applications [J].
Cai, Zeng-xiao ;
Mo, Xiu-mei ;
Zhang, Kui-hua ;
Fan, Lin-peng ;
Yin, An-lin ;
He, Chuang-long ;
Wang, Hong-sheng .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2010, 11 (09) :3529-3539
[3]   Norfloxacin-loaded chitosan sponges as wound dressing material [J].
Denkbas, EB ;
Öztürk, E ;
Özdemir, N ;
Keçeci, K .
JOURNAL OF BIOMATERIALS APPLICATIONS, 2004, 18 (04) :291-303
[4]  
Dumville JC, 2011, COCHRANE DB SYST REV, DOI [10.1002/14651858.CD009101.pub2, 10.1002/14651858.CD009099.pub3]
[5]   Moist wound healing with occlusive dressings: A clinical focus [J].
Eaglstein, WH .
DERMATOLOGIC SURGERY, 2001, 27 (02) :175-181
[6]   Melt blown nanofibers: Fiber diameter distributions and onset of fiber breakup [J].
Ellison, Christopher J. ;
Phatak, Alhad ;
Giles, David W. ;
Macosko, Christopher W. ;
Bates, Frank S. .
POLYMER, 2007, 48 (11) :3306-3316
[7]   Wound repair and regeneration [J].
Gurtner, Geoffrey C. ;
Werner, Sabine ;
Barrandon, Yann ;
Longaker, Michael T. .
NATURE, 2008, 453 (7193) :314-321
[8]   Dual-syringe reactive electrospinning of cross-linked hyaluronic acid hydrogel nanofibers for tissue engineering applications [J].
Ji, Yuan ;
Ghosh, Kaustabh ;
Li, Bingquan ;
Sokolov, Jonathan C. ;
Clark, Richard A. F. ;
Rafailovich, Miriam H. .
MACROMOLECULAR BIOSCIENCE, 2006, 6 (10) :811-817
[9]   Controlling wound bioburden with a novel silver-containing Hydrofiber® dressing [J].
Jones, SA ;
Bowler, PG ;
Walker, M ;
Parsons, D .
WOUND REPAIR AND REGENERATION, 2004, 12 (03) :288-294
[10]   Chitosan-Coated Poly(vinyl alcohol) Nanofibers For Wound Dressings [J].
Kang, Yun Ok ;
Yoon, In-Soo ;
Lee, So Young ;
Kim, Dae-Duk ;
Lee, Seung Jin ;
Park, Won Ho ;
Hudson, Samuel M. .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 2010, 92B (02) :568-576
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