Preparation of annulated nitrogen-containing heterocycles via a one-pot palladium-catalyzed alkylation/direct arylation sequence

被引：103
作者：
Blaszykowski, C [1 ]
Aktoudianakis, E [1 ]
Bressy, C [1 ]
Alberico, D [1 ]
Lautens, M [1 ]
机构：
[1] Univ Toronto, Dept Chem, Davenport Labs, Toronto, ON M5S 3H6, Canada
来源：
ORGANIC LETTERS | 2006年 / 8卷 / 10期
关键词：
D O I：
10.1021/ol060447y
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A palladium-catalyzed/norbornene-mediated sequential coupling reaction involving an aromatic Sp(2) C-H functionalization as the key step is described, in which an alkyl-aryl bond and an aryl-heteroaryl bond are formed in one pot. A variety of highly substituted six- and seven-membered annulated pyrroles and pyrazoles were synthesized in a one-step process in good yields from readily accessible N-bromoalkyl pyrroles or pyrazoles and aryl iodides.
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页码：2043 / 2045
页数：3
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