Multi-modulation of nuclear receptor coactivators through posttranslational modifications

被引：73
作者：
Han, Sang Jun [1 ]
Lonard, David M. [1 ]
O'Malley, Bert W. [1 ]
机构：
[1] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA
来源：
TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2009年 / 20卷 / 01期
关键词：
HUMAN BREAST-CANCER; STEROID-RECEPTOR; ESTROGEN-RECEPTOR; TRANSCRIPTIONAL COACTIVATOR; PROGESTERONE-RECEPTOR; HORMONE RECEPTOR; GENE ACTIVATION; PROTEIN; KINASE; PHOSPHORYLATION;
D O I：
10.1016/j.tem.2008.10.001
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Nuclear receptor (NR) coactivators are recruited to DNA by NRs, potentiating NR-dependent gene transcription. To obtain the complexity of NR-mediated gene regulation with a finite number of coactivators, the molecular properties of coactivators are dynamically modulated by posttranslational modifications (PTMs) in response to external stimuli. PTMs can regulate the molecular interactions of coactivators with transcription factors and other coactivators, in addition to their cellular location, protein stability, conformation and enzymatic activity. Therefore, dynamic regulation of the molecular properties of coactivators by PTMs allows for the complexity of NR-dependent gene expression and influences the regulation of NR-mediated physiological processes. This review focuses on recent progress in our understanding of how coactivator PTMs influence NR-mediated gene transcription and addresses their biological relevance.
引用
收藏
页码：8 / 15
页数：8
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