Integrative genomic analysis of the human immune response to influenza vaccination

被引：107

作者：

Franco, Luis M. ^{[1
,2
]}

Bucasas, Kristine L. ^{[1
]}

Wells, Janet M. ^{[3
]}

Nino, Diane ^{[3
]}

Wang, Xueqing ^{[4
]}

Zapata, Gladys E. ^{[4
]}

Arden, Nancy ^{[5
]}

Renwick, Alexander ^{[6
]}

Yu, Peng ^{[1
]}

Quarles, John M. ^{[5
]}

Bray, Molly S. ^{[4
]}

Couch, Robert B. ^{[2
,3
]}

Belmont, John W. ^{[1
,4
]}

Shaw, Chad A. ^{[1
]}

机构：

[1] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Med, Houston, TX 77030 USA

[3] Baylor Coll Med, Dept Mol Virol & Microbiol, Houston, TX 77030 USA

[4] Baylor Coll Med, Childrens Nutr Res Ctr, Houston, TX 77030 USA

[5] Texas A&M Univ, Syst Hlth Sci Ctr, Dept Microbial & Mol Pathogenesis, College Stn, TX USA

[6] Baylor Coll Med, Interdept Program Struct & Computat Biol & Mol Bi, Houston, TX 77030 USA

来源：

ELIFE | 2013年 / 2卷

基金：

美国国家卫生研究院;

关键词：

GENE-EXPRESSION; CELL-LINES; DISEASE; INFECTION; TOOL;

D O I：

10.7554/eLife.00299

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Identification of the host genetic factors that contribute to variation in vaccine responsiveness may uncover important mechanisms affecting vaccine efficacy. We carried out an integrative, longitudinal study combining genetic, transcriptional, and immunologic data in humans given seasonal influenza vaccine. We identified 20 genes exhibiting a transcriptional response to vaccination, significant genotype effects on gene expression, and correlation between the transcriptional and antibody responses. The results show that variation at the level of genes involved in membrane trafficking and antigen processing significantly influences the human response to influenza vaccination. More broadly, we demonstrate that an integrative study design is an efficient alternative to existing methods for the identification of genes involved in complex traits.

引用

页数：18

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