Integrative genomic analysis of the human immune response to influenza vaccination

被引：105

作者：

Franco, Luis M. ^{[1
,2
]}

Bucasas, Kristine L. ^{[1
]}

Wells, Janet M. ^{[3
]}

Nino, Diane ^{[3
]}

Wang, Xueqing ^{[4
]}

Zapata, Gladys E. ^{[4
]}

Arden, Nancy ^{[5
]}

Renwick, Alexander ^{[6
]}

Yu, Peng ^{[1
]}

Quarles, John M. ^{[5
]}

Bray, Molly S. ^{[4
]}

Couch, Robert B. ^{[2
,3
]}

Belmont, John W. ^{[1
,4
]}

Shaw, Chad A. ^{[1
]}

机构：

[1] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Med, Houston, TX 77030 USA

[3] Baylor Coll Med, Dept Mol Virol & Microbiol, Houston, TX 77030 USA

[4] Baylor Coll Med, Childrens Nutr Res Ctr, Houston, TX 77030 USA

[5] Texas A&M Univ, Syst Hlth Sci Ctr, Dept Microbial & Mol Pathogenesis, College Stn, TX USA

[6] Baylor Coll Med, Interdept Program Struct & Computat Biol & Mol Bi, Houston, TX 77030 USA

来源：

ELIFE | 2013年 / 2卷

基金：

美国国家卫生研究院;

关键词：

GENE-EXPRESSION; CELL-LINES; DISEASE; INFECTION; TOOL;

D O I：

10.7554/eLife.00299

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Identification of the host genetic factors that contribute to variation in vaccine responsiveness may uncover important mechanisms affecting vaccine efficacy. We carried out an integrative, longitudinal study combining genetic, transcriptional, and immunologic data in humans given seasonal influenza vaccine. We identified 20 genes exhibiting a transcriptional response to vaccination, significant genotype effects on gene expression, and correlation between the transcriptional and antibody responses. The results show that variation at the level of genes involved in membrane trafficking and antigen processing significantly influences the human response to influenza vaccination. More broadly, we demonstrate that an integrative study design is an efficient alternative to existing methods for the identification of genes involved in complex traits.

引用

页数：18

共 32 条

[1] Unbiased Reconstruction of a Mammalian Transcriptional Network Mediating Pathogen Responses
Amit, Ido
Garber, Manuel
Chevrier, Nicolas
Leite, Ana Paula
Donner, Yoni
Eisenhaure, Thomas
Guttman, Mitchell
Grenier, Jennifer K.
Li, Weibo
Zuk, Or
Schubert, Lisa A.
Birditt, Brian
Shay, Tal
Goren, Alon
Zhang, Xiaolan
Smith, Zachary
Deering, Raquel
McDonald, Rebecca C.
Cabili, Moran
Bernstein, Bradley E.
Rinn, John L.
Meissner, Alex
Root, David E.
Hacohen, Nir
Regev, Aviv
[J]. SCIENCE, 2009, 326 (5950) : 257 - 263
[2] Deciphering the genetic architecture of variation in the immune response to Mycobacterium tuberculosis infection
Barreiro, Luis B.
Tailleux, Ludovic
Pai, Athma A.
Gicquel, Brigitte
Marioni, John C.
Gilad, Yoav
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (04) : 1204 - 1209
[3] Early Patterns of Gene Expression Correlate With the Humoral Immune Response to Influenza Vaccination in Humans
Bucasas, Kristine L.
Franco, Luis M.
Shaw, Chad A.
Bray, Molly S.
Wells, Janet M.
Nino, Diane
Arden, Nancy
Quarles, John M.
Couch, Robert B.
Belmont, John W.
[J]. JOURNAL OF INFECTIOUS DISEASES, 2011, 203 (07) : 921 - 929
[4] Expression quantitative trait loci detected in cell lines are often present in primary tissues
Bullaughey, Kevin
Chavarria, Claudia I.
Coop, Graham
Gilad, Yoav
[J]. HUMAN MOLECULAR GENETICS, 2009, 18 (22) : 4296 - 4303
[5] Mapping complex disease traits with global gene expression
Cookson, William
Liang, Liming
Abecasis, Goncalo
Moffatt, Miriam
Lathrop, Mark
[J]. NATURE REVIEWS GENETICS, 2009, 10 (03) : 184 - 194
[6] DAVID: Database for annotation, visualization, and integrated discovery
Dennis, G
Sherman, BT
Hosack, DA
Yang, J
Gao, W
Lane, HC
Lempicki, RA
[J]. GENOME BIOLOGY, 2003, 4 (09)
[7] Dowdle WN, 1979, DIAGNOSTIC PROCEDURE, P603
[8] lumi:: a pipeline for processing Illumina microarray
Du, Pan
Kibbe, Warren A.
Lin, Simon M.
[J]. BIOINFORMATICS, 2008, 24 (13) : 1547 - 1548
[9] Genetics of gene expression and its effect on disease
Emilsson, Valur
Thorleifsson, Gudmar
Zhang, Bin
Leonardson, Amy S.
Zink, Florian
Zhu, Jun
Carlson, Sonia
Helgason, Agnar
Walters, G. Bragi
Gunnarsdottir, Steinunn
Mouy, Magali
Steinthorsdottir, Valgerdur
Eiriksdottir, Gudrun H.
Bjornsdottir, Gyda
Reynisdottir, Inga
Gudbjartsson, Daniel
Helgadottir, Anna
Jonasdottir, Aslaug
Jonasdottir, Adalbjorg
Styrkarsdottir, Unnur
Gretarsdottir, Solveig
Magnusson, Kristinn P.
Stefansson, Hreinn
Fossdal, Ragnheidur
Kristjansson, Kristleifur
Gislason, Hjortur G.
Stefansson, Tryggvi
Leifsson, Bjorn G.
Thorsteinsdottir, Unnur
Lamb, John R.
Gulcher, Jeffrey R.
Reitman, Marc L.
Kong, Augustine
Schadt, Eric E.
Stefansson, Kari
[J]. NATURE, 2008, 452 (7186) : 423 - U2
[10] MICRONEUTRALIZATION TEST FOR INFLUENZA-A AND INFLUENZA-B AND PARA-INFLUENZA-1 AND PARAINFLUENZA-2 VIRUSES THAT USES CONTINUOUS CELL-LINES AND FRESH SERUM ENHANCEMENT
FRANK, AL
PUCK, J
HUGHES, BJ
CATE, TR
[J]. JOURNAL OF CLINICAL MICROBIOLOGY, 1980, 12 (03) : 426 - 432

← 1 2 3 4 →