T Follicular Helper Cell Biology: A Decade of Discovery and Diseases

被引：1066

作者：

Crotty, Shane ^{[1
,2
,3
]}

机构：

[1] La Jolla Inst Immunol LJI, Div Vaccine Discovery, La Jolla, CA 92037 USA

[2] Scripps Res, Ctr HIV AIDS Vaccine Immunol & Immunogen Discover, La Jolla, CA 92037 USA

[3] Univ Calif San Diego, Dept Med, La Jolla, CA 92037 USA

来源：

IMMUNITY | 2019年 / 50卷 / 05期

基金：

美国国家卫生研究院;

关键词：

GERMINAL CENTER RESPONSES; CENTER B-CELLS; NEUTRALIZING ANTIBODY-RESPONSES; TRANSCRIPTION FACTOR; TFH CELLS; FH CELLS; DYNAMIC REGULATION; HUMORAL RESPONSES; NONHUMAN-PRIMATES; REGULATORY CELLS;

D O I：

10.1016/j.immuni.2019.04.011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Helping B cells and antibody responses is a major function of CD4(+) T cells. It has been 10 years since the publication of Bcl6 as the lineage-defining transcription factor for T follicular helper (Tfh) differentiation and the requirement of Tfh cells as the specialized subset of CD4(+) T cells needed for germinal centers (the microanatomical sites of B cell mutation and antibody affinity maturation) and related B cell responses. A great deal has been learned about Tfh cells in the past 10 years, particularly regarding their roles in a surprising range of diseases. Advances in the understanding of Tfh cell differentiation and function are discussed, as are the understanding of Tfh cells in infectious diseases, vaccines, autoimmune diseases, allergies, atherosclerosis, organ transplants, and cancer. This includes discussion of Tfh cells in the human immune system. Based on the discoveries to date, the next decade of Tfh research surely holds many more surprises.

引用

页码：1132 / 1148

页数：17

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