Novel arylsulfoanilide-oxindole hybrid as an anticancer agent that inhibits translation initiation

被引：181

作者：

Natarajan, A ^{[1
]}

Guo, YH ^{[1
]}

Harbinski, F ^{[1
]}

Fan, YH ^{[1
]}

Chen, H ^{[1
]}

Luus, L ^{[1
]}

Diercks, J ^{[1
]}

Aktas, H ^{[1
]}

Chorev, M ^{[1
]}

Halperin, JA ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Lab Translat Res, Cambridge, MA 02139 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2004年 / 47卷 / 21期

关键词：

D O I：

10.1021/jm0496234

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Structure-activity relationship studies of substituted arylsulfoanilides as antiproliferatives, which are mediated by the partial depletion of intracellular Ca2+ stores, resulted in the identification of compounds with micromolar activity against lung cancer cells in a growth inhibition assay. Incorporating the substitution pattern of the best arylsulfoanilides onto the 3-phenyloxindole scaffold resulted in a potent arylsulfoanilide-oxindole hybrid, 27. Compound 27 inhibits cancer cell growth by partial depletion of intracellular Ca2+ stores and phosphorylation of eIF2alpha.

引用

页码：4979 / 4982

页数：4

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