Direct Catalytic Synthesis of Unprotected 2-Amino-1-Phenylethanols from Alkenes by Using Iron(II) Phthalocyanine

被引：118
作者：
Legnani, Luca [1 ]
Morandi, Bill [1 ]
机构：
[1] Max Planck Inst Kohlenforsch, D-45470 Mulheim, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2016年 / 55卷 / 06期
关键词：
alkenes; amino alcohols; bioactive compounds; homogeneous catalysis; iron; INTERMOLECULAR AMINOACETOXYLATION; HETEROCYCLE SYNTHESIS; AMINOHYDROXYLATION; OLEFINS; AMINOOXYGENATION; AMINOPALLADATION; AZIRIDINATION; OXYAMINATION; REACTIVITY; OXAZOLINES;
D O I：
10.1002/anie.201507630
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Aryl-substituted amino alcohols are privileged scaffolds in medicinal chemistry and natural products. Herein, we report that an exceptionally simple and inexpensive Fe-II complex efficiently catalyzes the direct transformation of simple alkenes into unprotected amino alcohols in good yield and perfect regioselectivity. This new catalytic method was applied in the expedient synthesis of bioactive molecules and could be extended to aminoetherification.
引用
收藏
页码：2248 / 2251
页数：4
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