Biomarkers predictive value for early diagnosis of Stroke-Associated Pneumonia

被引：23

作者：

Zapata-Arriaza, Elena ^{[1
]}

Mancha, Fernando ^{[1
]}

Bustamante, Alejandro ^{[2
]}

Moniche, Francisco ^{[1
,3
]}

Pardo-Galiana, Blanca ^{[1
,3
]}

Serrano-Gotarredona, Pilar ^{[4
]}

Navarro-Herrero, Silvia ^{[4
]}

Pallisa, Esther ^{[5
]}

Faura, Julia ^{[2
]}

Vega-Salvatierra, Angela ^{[1
]}

Penalba, Anna ^{[2
]}

Escudero-Martinez, Irene ^{[1
,3
]}

Dario Ramos-Herrero, Victor ^{[1
]}

Azurmendi, Leire ^{[6
]}

Sanchez, Jean Charles ^{[6
]}

Montaner, Joan ^{[1
]}

机构：

[1] Univ Seville, Stroke Res Program, Inst Biomed Seville, IBiS,Hosp Univ Virgen del Rocio,CSIC, Seville, Spain

[2] Univ Autonoma Barcelona, VHIR, Neurovasc Res Lab, Barcelona, Spain

[3] Hosp Univ Virgen del Rocio, Dept Neurol, Seville, Spain

[4] Univ Hosp Virgen del Rocio, Radiol Dept, Seville, Spain

[5] Vall dHebron Univ Hosp, Dept Radiol, Barcelona, Spain

[6] Univ Geneva, Dept Human Prot Sci, Geneva, Switzerland

来源：

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY | 2019年 / 6卷 / 09期

关键词：

VALIDATION; CRITERIA;

D O I：

10.1002/acn3.50849

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

To confirm the diagnostic accuracy of candidate biomarkers in stroke-associated pneumonia (SAP), we prospectively enrolled ischemic stroke patients with NIHSS >= 10 on admission from March-2016 to August-2017. Blood samples were collected at baseline, 24 and 48 h after stroke onset. Biomarkers (MR-proADM, suPAR, SAA) were determined by immunoassays. Regarding biomarkers, MR-proADM at 24 h (P = 0.04) and both suPAR and SAA at 48 h (P = 0.036 and P = 0.057) were associated with pneumonia. The combination of SAA > 25.15 mg/dL and suPAR> 3.14 ng/mL at 48 h had 80% sensitivity and 95.8% specificity when both biomarkers were above the cut-off. The evaluated biomarkers represent promising tools to be evaluated in future large, prospective studies on SAP. An accurate SAP diagnosis by thorax CT might help to reduce variability in such studies.

引用

页码：1882 / 1887

页数：6

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