Head Start Immunity: Characterizing the Early Protection of C Strain Vaccine Against Subsequent Classical Swine Fever Virus Infection

被引：12

作者：

McCarthy, Ronan R. ^{[1
,4
]}

Everett, Helen E. ^{[1
]}

Graham, Simon P. ^{[1
,2
,3
]}

Steinbach, Falko ^{[1
,2
]}

Crooke, Helen R. ^{[1
]}

机构：

[1] Anim & Plant Hlth Agcy, Virol Dept, Addlestone, Surrey, England

[2] Univ Surrey, Sch Vet Med, Guildford, Surrey, England

[3] Pirbright Inst, Pirbright, England

[4] Brunel Univ, Coll Hlth & Life Sci, Dept Life Sci, Div Biosci, Heinz Wolff Bldg,Kingston Lane, Uxbridge, Middx, England

来源：

FRONTIERS IN IMMUNOLOGY | 2019年 / 10卷

关键词：

swine; CSFV; innate; C Strain; ISG15; antiviral; vaccination; INTERFERON-ALPHA; GENE ONTOLOGY; NS1; PROTEIN; EXPRESSION; IDENTIFICATION; CONJUGATION; DISEASE; CELLS; CSFV; TRANSMISSION;

D O I：

10.3389/fimmu.2019.01584

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Classical Swine Fever Virus (CSFV) is an ongoing threat to the pig industry due to the high transmission and mortality rates associated with infection. Live attenuated vaccines such as the CSFV C strain vaccine are capable of protecting against infection within 5 days of vaccination, but the molecular mechanisms through which this early protection is mediated have yet to be established. In this study, we compared the response of pigs vaccinated with the C strain to non-vaccinated pigs both challenged with a pathogenic strain of CSFV. Analysis of transcriptomic data from the tonsils of these animals during the early stages after vaccination and challenge reveals a set of regulated genes that appear throughout the analysis. Many of these are linked to the ISG15 antiviral pathway suggesting it may play a role in the rapid and early protection conferred by C strain vaccination.

引用

页数：11

共 58 条

[1] Where, in antiviral defense, does IFIT1 fit? [J].

Ablasser, Andrea ;

Hornung, Veit .

NATURE IMMUNOLOGY, 2011, 12 (07) :588-590

[2]

[Anonymous], 2012, INFECT DIS WILD MAMM

[3] Gene Ontology: tool for the unification of biology [J].

Ashburner, M ;

Ball, CA ;

Blake, JA ;

Botstein, D ;

Butler, H ;

Cherry, JM ;

Davis, AP ;

Dolinski, K ;

Dwight, SS ;

Eppig, JT ;

Harris, MA ;

Hill, DP ;

Issel-Tarver, L ;

Kasarskis, A ;

Lewis, S ;

Matese, JC ;

Richardson, JE ;

Ringwald, M ;

Rubin, GM ;

Sherlock, G .

NATURE GENETICS, 2000, 25 (01) :25-29

[4] Gene Ontology Consortium: going forward [J].

Blake, J. A. ;

Christie, K. R. ;

Dolan, M. E. ;

Drabkin, H. J. ;

Hill, D. P. ;

Ni, L. ;

Sitnikov, D. ;

Burgess, S. ;

Buza, T. ;

Gresham, C. ;

McCarthy, F. ;

Pillai, L. ;

Wang, H. ;

Carbon, S. ;

Dietze, H. ;

Lewis, S. E. ;

Mungall, C. J. ;

Munoz-Torres, M. C. ;

Feuermann, M. ;

Gaudet, P. ;

Basu, S. ;

Chisholm, R. L. ;

Dodson, R. J. ;

Fey, P. ;

Mi, H. ;

Thomas, P. D. ;

Muruganujan, A. ;

Poudel, S. ;

Hu, J. C. ;

Aleksander, S. A. ;

McIntosh, B. K. ;

Renfro, D. P. ;

Siegele, D. A. ;

Attrill, H. ;

Brown, N. H. ;

Tweedie, S. ;

Lomax, J. ;

Osumi-Sutherland, D. ;

Parkinson, H. ;

Roncaglia, P. ;

Lovering, R. C. ;

Talmud, P. J. ;

Humphries, S. E. ;

Denny, P. ;

Campbell, N. H. ;

Foulger, R. E. ;

Chibucos, M. C. ;

Giglio, M. Gwinn ;

Chang, H. Y. ;

Finn, R. .

NUCLEIC ACIDS RESEARCH, 2015, 43 (D1) :D1049-D1056

[5] Classical Swine Fever-An Updated Review [J].

Blome, Sandra ;

Staubach, Christoph ;

Henke, Julia ;

Carlson, Jolene ;

Beer, Martin .

VIRUSES-BASEL, 2017, 9 (04) :1-24

[6] A Review of Classical Swine Fever Virus and Routes of Introduction into the United States and the Potential for Virus Establishment [J].

Brown, Vienna R. ;

Bevins, Sarah N. .

FRONTIERS IN VETERINARY SCIENCE, 2018, 5

[7] Infection with Classical Swine Fever Virus Induces Expression of Type III Interferons and Activates Innate Immune Signaling [J].

Cai, Binxiang ;

Bai, Qingling ;

Chi, Xiaojuan ;

Goraya, Mohsan U. ;

Wang, Long ;

Wang, Song ;

Chen, Biao ;

Chen, Ji-Long .

FRONTIERS IN MICROBIOLOGY, 2017, 8

[8] Expression of bovine Mx1 protein inhibits the replication of foot-and-mouth disease virus in BHK-21 cells [J].

Cai, K. J. ;

Meng, Q. L. ;

Qiao, J. ;

Huang, J. ;

Zhang, Z. C. ;

Wang, G. C. ;

Wang, J. W. ;

Chen, C. F. .

ACTA VIROLOGICA, 2013, 57 (04) :429-434

[9] A comparison of the impact of Shimen and C strains of classical swine fever virus on Toll-like receptor expression [J].

Cao, Zhi ;

Guo, Kangkang ;

Zheng, Minping ;

Ning, Pengbo ;

Li, Helin ;

Kang, Kai ;

Lin, Zhi ;

Zhang, Chengcheng ;

Liang, Wulong ;

Zhang, Yanming .

JOURNAL OF GENERAL VIROLOGY, 2015, 96 :1732-1745

[10] A Role for Ifit2 in Restricting West Nile Virus Infection in the Brain [J].

Cho, Hyelim ;

Shrestha, Bimmi ;

Sen, Ganes C. ;

Diamond, Michael S. .

JOURNAL OF VIROLOGY, 2013, 87 (15) :8363-8371

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