The genus Hypericum -: a valuable resource of anti-Staphylococcal leads

被引：60

作者：

Gibbons, S

Ohlendorf, B

Johnsen, I

机构：

[1] Univ London, Sch Pharm, Ctr Pharmacognosy & Phytotherapy, London WC1N 1AX, England

[2] Univ Heidelberg, Inst Pharmazeut Technol & Biopharm, D-69120 Heidelberg, Germany

来源：

FITOTERAPIA | 2002年 / 73卷 / 04期

关键词：

Hypericum; antibacterial activity;

D O I：

10.1016/S0367-326X(02)00082-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In the present study, extracts of 34 species and varieties of the genus Hypericum were screened for activity against a clinical isolate of methicillin-resistant Staphylococcus aureus, which in addition possessed a multidrug efflux mechanism conferring a high level of resistance to therapeutically useful antibiotics. Thirty-three of the 34 chloroform extracts showed significant activity in a disk diffusion assay, and five extracts had minimum inhibitory concentrations of 64 mug/ml, indicating that this genus has great potential to yield compounds with potent activity against multidrug-resistant bacteria. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：300 / 304

页数：5

共 14 条

[1] KEY ANTIFUNGAL, ANTIBACTERIAL AND ANTIINSECT ASSAYS - A CRITICAL-REVIEW [J].