Protein biomarkers in a mouse model of extremes in trait anxiety

被引：61

作者：

Ditzen, Claudia ^{[1
]}

Jastorff, Archana M. ^{[1
]}

Kessler, Melanie S. ^{[1
]}

Bunck, Mirjam ^{[1
]}

Teplytska, Larysa ^{[1
]}

Erhardt, Angelika ^{[1
]}

Kroemer, Simone A. ^{[1
]}

Varadarajulu, Jeeva ^{[1
]}

Targosz, Bianca-Sabrina ^{[1
]}

Sayan-Ayata, Eser F. ^{[1
]}

Holsboer, Florian ^{[1
]}

Landgraf, Rainer ^{[1
]}

Turck, Christoph W. ^{[1
]}

机构：

[1] Max Planck Inst Psychiat, D-80804 Munich, Germany

来源：

MOLECULAR & CELLULAR PROTEOMICS | 2006年 / 5卷 / 10期

关键词：

D O I：

10.1074/mcp.M600088-MCP200

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Brain proteome analysis of mice selectively bred for either high or low anxiety-related behavior revealed quantitative and qualitative protein expression differences. The enzyme glyoxalase-I was consistently expressed to a higher extent in low anxiety as compared with high anxiety mice in several brain areas. The same phenotype-dependent difference was also found in red blood cells with normal and cross-mated animals showing intermediate expression profiles of glyoxalase-I. Another protein that showed a different mobility during two-dimensional gel electrophoresis was identified as enolase phosphatase. The presence of both protein markers in red or white blood cells, respectively, creates the opportunity to screen for their expression in clinical blood specimens from patients suffering from anxiety.

引用

页码：1914 / 1920

页数：7

共 24 条

[1] The syracuse strains, selectively bred for differences in active avoidance learning, may be models of genetic differences in trait and state anxiety [J].