Transcriptomic insights into temporal expression pattern of autophagy genes during monocytic and granulocytic differentiation

被引：13

作者：

Huang, Yan ^{[1
]}

Tan, Puwen ^{[1
]}

Wang, Xiaoshuang ^{[2
,3
]}

Yi, Ying ^{[1
]}

Hu, Yongfei ^{[1
]}

Wang, Dong ^{[1
,4
]}

Wang, Fang ^{[2
,3
]}

机构：

[1] Harbin Med Univ, Coll Bioinformat Sci & Technol, 157 Baojian Rd, Harbin, Heilongjiang, Peoples R China

[2] Chinese Acad Med Sci, Inst Basic Med Sci, Dept Biochem & Mol Biol, State Key Lab Med Mol Biol, Beijing, Peoples R China

[3] Peking Union Med Coll, Beijing, Peoples R China

[4] Univ Elect Sci & Technol China, Ctr Informat Biol, Chengdu, Sichuan, Peoples R China

来源：

AUTOPHAGY | 2018年 / 14卷 / 03期

基金：

中国国家自然科学基金;

关键词：

autophagy; hematopoietic stem cell; monocytic and granulocytic differentiation; temporal expression pattern; transcriptomic analysis;

D O I：

10.1080/15548627.2018.1425060

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Macroautophagy/autophagy plays an essential role in hematopoietic stem cell (HSC) differentiation. However, the role of autophagy during monocytic and granulocytic differentiation remains poorly understood. Hence, we first represented global transcriptomic analysis for temporal expression of autophagy genes during monocytic and granulocytic differentiation by combining RNA-Seq data with monocytic and granulocytic induction in CD34(+) hematopoietic stem and progenitor cells. According to a self-organizing map (SOM) algorithm, our results show temporal expression patterns of autophagy genes during monocytic and granulocytic differentiation. More importantly, 22 autophagy genes present significantly divergent roles during monocytic and granulocytic differentiation, indicating these autophagy genes could be important factors involved in the differentiation of myeloid progenitors into monocytes and granulocytes.

引用

页码：558 / 559

页数：2