Construction of Bridged Aza- and Oxa-[n.2.1] Skeletons via an Intramolecular Formal [3+2] Cycloaddition of Aziridines and Epoxides with Electron-Deficient Alkenes

被引：6

作者：

Xing, Siyang ^{[1
]}

Wang, Yuhan ^{[1
]}

Jin, Changkun ^{[1
]}

Shi, Shaochen ^{[1
]}

Zhang, Yihui ^{[1
]}

Liao, Ziya ^{[1
]}

Wang, Kui ^{[1
]}

Zhu, Bolin ^{[1
]}

机构：

[1] Tianjin Normal Univ, Coll Chem, Tianjin Key Lab Struct & Performance Funct Mol, Tianjin 300387, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 87卷 / 09期

关键词：

STEREOSELECTIVE-SYNTHESIS; TANDEM; CYCLOPROPENES; DERIVATIVES; CYCLIZATION; EFFICIENT; CARBONYLS; SYSTEMS; FACILE; ENTRY;

D O I：

10.1021/acs.joc.2c00287

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An intramolecular formal [3+2] cycloaddition of activated aziridines and epoxides with electron-deficient alkene has been developed for the general and efficient construction of bridged aza- and oxa-[n.2.1] (n = 3 or 4) skeletons. This strategy can be efficiently promoted by lithium iodide. To demonstrate its potential, the intramolecular formal [3+2] cycloaddition was used to access the important intermediate of homoepiboxidine

引用

页码：6426 / 6431

页数：6

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