The multifaceted role of TRAIL signaling in cancer and immunity

被引：83
作者：
Alves, Ludmila Cardoso [1 ]
Corazza, Nadia [1 ]
Micheau, Olivier [2 ]
Krebs, Philippe [1 ]
机构：
[1] Univ Bern, Inst Pathol, Bern, Switzerland
[2] Univ Bourgogne Franche Comte, INSERM, LNC UMR1231, Dijon, France
来源：
FEBS JOURNAL | 2021年 / 288卷 / 19期
基金：
瑞士国家科学基金会; 欧盟地平线“2020”;
关键词：
apoptosis; cancer; immune cell regulation; NK cells; noncanonical TRAIL signaling; TRAIL signaling; APOPTOSIS-INDUCING LIGAND; NF-KAPPA-B; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; HUMAN DENDRITIC CELLS; NATURAL-KILLER-CELLS; FACTOR-RECEPTOR SUPERFAMILY; FADD-DEPENDENT APOPTOSIS; ACTIVATION-INDUCED DEATH; HUMAN T-CELLS; MEDIATED APOPTOSIS;
D O I：
10.1111/febs.15637
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily that can lead to the induction of apoptosis in tumor or infected cells. However, activation of TRAIL signaling may also trigger nonapoptotic pathways in cancer and in nontransformed cells, that is, immune cells. Here, we review the current knowledge on noncanonical TRAIL signaling. The biological outcomes of TRAIL signaling in immune and malignant cells are presented and explained, with a focus on the role of TRAIL for natural killer (NK) cell function. Furthermore, we highlight the technical difficulties in dissecting the precise molecular mechanisms involved in the switch between apoptotic and nonapoptotic TRAIL signaling. Finally, we discuss the consequences thereof for a therapeutic manipulation of TRAIL in cancer and possible approaches to bypass these difficulties.
引用
收藏
页码：5530 / 5554
页数：25
相关论文
共 265 条
[1]   Oncolytic measles virus induces tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated cytotoxicity by human myeloid and plasmacytoid dendritic cells [J].
Achard, Carole ;
Guillerme, Jean-Baptiste ;
Bruni, Daniela ;
Boisgerault, Nicolas ;
Combredet, Chantal ;
Tangy, Frederic ;
Jouvenet, Nolwenn ;
Gregoire, Marc ;
Fonteneau, Jean-Francois .
ONCOIMMUNOLOGY, 2017, 6 (01)
[2]   Natural Killer Cells Are Polarized Toward Cytotoxicity in Chronic Hepatitis C in an Interferon-Alfa-Dependent Manner [J].
Ahlenstiel, Golo ;
Titerence, Rachel H. ;
Koh, Christopher ;
Edlich, Birgit ;
Feld, Jordan J. ;
Rotman, Yaron ;
Ghany, Marc G. ;
Hoofnagle, Jay H. ;
Liang, T. Jake ;
Heller, Theo ;
Rehermann, Barbara .
GASTROENTEROLOGY, 2010, 138 (01) :325-335
[3]   TNF receptor family signaling in the development and functions of medullary thymic epithelial cells [J].
Akiyama, Taishin ;
Shinzawa, Miho ;
Akiyama, Nobuko .
FRONTIERS IN IMMUNOLOGY, 2012, 3
[4]   Non-apoptotic TRAIL function modulates NK cell activity during viral infection [J].
Alves, Ludmila Cardoso ;
Berger, Michael D. ;
Koutsandreas, Thodoris ;
Kirschke, Nick ;
Lauer, Christoph ;
Sporri, Roman ;
Chatziioannou, Aristotelis ;
Corazza, Nadia ;
Krebs, Philippe .
EMBO REPORTS, 2020, 21 (01)
[5]   Safety and antitumor activity of recombinant soluble Apo2 ligand [J].
Ashkenazi, A ;
Pai, RC ;
Fong, S ;
Leung, S ;
Lawrence, DA ;
Masters, SA ;
Blackie, C ;
Chang, L ;
McMurtrey, AE ;
Hebert, A ;
DeForge, L ;
Koumenis, IL ;
Lewis, D ;
Harris, L ;
Bussiere, J ;
Koeppen, H ;
Shahrokh, Z ;
Schwall, RH .
JOURNAL OF CLINICAL INVESTIGATION, 1999, 104 (02) :155-162
[6]   Non-canonical kinase signaling by the death ligand TRAIL in cancer cells: discord in the death receptor family [J].
Azijli, K. ;
Weyhenmeyer, B. ;
Peters, G. J. ;
de Jong, S. ;
Kruyt, F. A. E. .
CELL DEATH AND DIFFERENTIATION, 2013, 20 (07) :858-868
[7]   Kinome profiling of non-canonical TRAIL signaling reveals RIP1-Src-STAT3-dependent invasion in resistant non-small cell lung cancer cells [J].
Azijli, Kaamar ;
Yuvaraj, Saravanan ;
Peppelenbosch, Maikel P. ;
Wurdinger, Thomas ;
Dekker, Henk ;
Joore, Jos ;
van Dijk, Evert ;
Quax, Wim J. ;
Peters, Godefridus J. ;
de Jong, Steven ;
Kruyt, Frank A. E. .
JOURNAL OF CELL SCIENCE, 2012, 125 (19) :4651-4661
[8]   TRAIL deficiency delays, but does not prevent, erosion in the quality of "helpless" memory CD8 T cells [J].
Badovinac, Vladimir P. ;
Messingham, Kelly A. Nordyke ;
Griffith, Thomas S. ;
Harty, John T. .
JOURNAL OF IMMUNOLOGY, 2006, 177 (02) :999-1006
[9]   Cancer-related inflammation: Common themes and therapeutic opportunities [J].
Balkwill, Frances R. ;
Mantovani, Alberto .
SEMINARS IN CANCER BIOLOGY, 2012, 22 (01) :33-40
[10]   Six1 overexpression in ovarian carcinoma causes resistance to TRAIL-mediated apoptosis and is associated with poor survival [J].
Behbakht, Kian ;
Qamar, Lubna ;
Aldridge, Carrie S. ;
Coletta, Ricardo D. ;
Davidson, Susan A. ;
Thorburn, Andrew ;
Ford, Heide L. .
CANCER RESEARCH, 2007, 67 (07) :3036-3042
12345678910