A path forward for the chlamydial virulence factor CPAF

被引：21

作者：

Conrad, Turner A. ^{[1
]}

Yang, Zhangsheng ^{[1
]}

Ojcius, David ^{[2
]}

Zhong, Guangming ^{[1
]}

机构：

[1] Univ Texas Hlth Sci Ctr San Antonio, Dept Microbiol & Immunol, San Antonio, TX 78229 USA

[2] Univ Calif, Sch Nat Sci, Merced, CA 95343 USA

来源：

MICROBES AND INFECTION | 2013年 / 15卷 / 14-15期

关键词：

CPAF; Substrates; Chlamydial virulence factors and pathogenesis; HUMAN-ANTIBODY RESPONSES; SECRETED PROTEASE CPAF; HOST-CELL CYTOPLASM; TRANSCRIPTIONAL REGULATOR; TRACHOMATIS SECRETION; PROTECTIVE IMMUNITY; PLASMID; INFECTION; IDENTIFICATION; VACCINATION;

D O I：

10.1016/j.micinf.2013.09.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CPAF is a conserved and secreted protease from obligate intracellular bacteria of the order Chlamydiales. Recently, it was demonstrated that most of its host targets are an artifact of inaccurate methods. This review aims to summarize key features of CPAF and propose new approaches for evaluating its role in chlamydial pathogenesis. (C) 2013 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

引用

页码：1026 / 1032

页数：7

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