Perspectives in immunotherapy: meeting report from the "Immunotherapy Bridge" (December 4th-5th, 2019, Naples, Italy)

被引：3

作者：

Ascierto, Paolo A. ^{[1
]}

Butterfield, Lisa H. ^{[2
]}

Campbell, Katie ^{[2
]}

Daniele, Bruno ^{[3
]}

Dougan, Michael ^{[4
]}

Emens, Leisha A. ^{[5
]}

Formenti, Silvia ^{[6
]}

Janku, Filip ^{[7
]}

Khleif, Samir N. ^{[8
]}

Kirchhoff, Tomas ^{[9
]}

Morabito, Alessandro ^{[10
]}

Najjar, Yana ^{[5
]}

Nathan, Paul ^{[11
]}

Odunsi, Kunle ^{[12
,13
]}

Patnaik, Akash ^{[14
]}

Paulos, Chrystal M. ^{[15
]}

Reinfeld, Bradley I. ^{[16
]}

Skinner, Heath D. ^{[17
]}

Timmerman, John ^{[18
]}

Puzanov, Igor ^{[19
]}

机构：

[1] Ist Nazl Tumori IRCCS Fdn G Pascale, Canc Unit Melanoma Canc Immunotherapy & Dev Thera, Canc Immunotherapy & Innovat Therapy, Via Mariano Semmola, I-80131 Naples, Italy

[2] Parker Inst Canc Immunotherapy, PICI Res & Dev, San Francisco, CA USA

[3] Osped Mare, Oncol Unit, Naples, Italy

[4] Harvard Med Sch, Massachusetts Gen Hosp, Boston, MA 02115 USA

[5] Univ Pittsburgh, UPMC Hillman Canc Ctr, Pittsburgh, PA USA

[6] Weill Cornell Med, Dept Radiat Oncol, Sandra & Edward Meyer Canc Ctr, New York, NY USA

[7] Univ Texas MD Anderson Canc Ctr, Div Canc Med, Dept Invest Canc Therapeut, Houston, TX 77030 USA

[8] Georgetown Univ, Loop Immunooncol Res Lab, Lombardi Canc Ctr, Washington, DC USA

[9] NYU, Sch Med, Perlmutter Canc Ctr, New York, NY USA

[10] IRCCS Fdn G Pascale, Natl Canc Inst, Thorac Med Oncol, Naples, Italy

[11] Mt Vernon Canc Ctr, Northwood, Middx, England

[12] Roswell Park Comprehens Canc Ctr, Ctr Immunotherapy, Buffalo, NY USA

[13] Roswell Park Comprehens Canc Ctr, Dept Gynecol Oncol, Buffalo, NY USA

[14] Univ Chicago, Dept Med, Sect Hematol & Oncol, 5841 S Maryland Ave, Chicago, IL 60637 USA

[15] Emory Univ, Winship Canc Inst, Atlanta, GA 30322 USA

[16] Vanderbilt Univ, Med Ctr, Nashville, TN USA

[17] Univ Pittsburgh, Dept Radiat Oncol, UPMC Hillman Canc Ctr, Pittsburgh, PA USA

[18] Univ Calif Los Angeles, Los Angeles, CA USA

[19] Roswell Park Comprehens Canc Ctr, Buffalo, NY USA

来源：

JOURNAL OF TRANSLATIONAL MEDICINE | 2021年 / 19卷 / 01期

关键词：

Immunotherapy; Checkpoint inhibitors; Combination therapy; Biomarkers; Tumor microenvironment; Vaccine; MERKEL CELL-CARCINOMA; STAGE-III MELANOMA; ANTITUMOR IMMUNITY; PD-1; BLOCKADE; PATIENTS PTS; NECK-CANCER; PEMBROLIZUMAB; NIVOLUMAB; IPILIMUMAB; THERAPY;

D O I：

10.1186/s12967-020-02627-y

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Over the last few years, numerous clinical trials and real-world experience have provided a large amount of evidence demonstrating the potential for long-term survival with immunotherapy agents across various malignancies, beginning with melanoma and extending to other tumours. The clinical success of immune checkpoint blockade has encouraged increasing development of other immunotherapies. It has been estimated that there are over 3000 immuno-oncology trials ongoing, targeting hundreds of disease and immune pathways. Evolving topics on cancer immunotherapy, including the state of the art of immunotherapy across various malignancies, were the focus of discussions at the Immunotherapy Bridge meeting (4-5 December, 2019, Naples, Italy), and are summarised in this report.

引用

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