The role of immune dysfunction in obesity-associated cancer risk, progression, and metastasis

被引：32
作者：
Kulkarni, Aneesha [1 ]
Bowers, Laura W. [1 ]
机构：
[1] Purdue Univ, Coll Hlth & Human Sci, Dept Nutr Sci, W Lafayette, IN 47906 USA
来源：
CELLULAR AND MOLECULAR LIFE SCIENCES | 2021年 / 78卷 / 07期
关键词：
Immunotherapy; Leptin; Chemoresistance; BODY-MASS INDEX; MONOCYTE CHEMOATTRACTANT PROTEIN-1; EPITHELIAL-MESENCHYMAL TRANSITION; TUMOR-ASSOCIATED MACROPHAGES; ADIPOSE-TISSUE MACROPHAGES; NECROSIS-FACTOR-ALPHA; DIET-INDUCED OBESITY; BREAST-CANCER; INSULIN-RESISTANCE; LEPTIN RECEPTOR;
D O I：
10.1007/s00018-020-03752-z
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Obesity has been linked to an increased risk of and a worse prognosis for several types of cancer. A number of interrelated mediators contribute to obesity's pro-tumor effects, including chronic adipose inflammation and other perturbations of immune cell development and function. Here, we review studies examining the impact of obesity-induced immune dysfunction on cancer risk and progression. While the role of adipose tissue inflammation in obesity-associated cancer risk has been well characterized, the effects of obesity on immune cell infiltration and activity within the tumor microenvironment are not well studied. In this review, we aim to highlight the impact of both adipose-mediated inflammatory signaling and intratumoral immunosuppressive signaling in obesity-induced cancer risk, progression, and metastasis.
引用
收藏
页码：3423 / 3442
页数：20
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