The role of immune dysfunction in obesity-associated cancer risk, progression, and metastasis

被引：32
|
作者：
Kulkarni, Aneesha [1 ]
Bowers, Laura W. [1 ]
机构：
[1] Purdue Univ, Coll Hlth & Human Sci, Dept Nutr Sci, W Lafayette, IN 47906 USA
来源：
CELLULAR AND MOLECULAR LIFE SCIENCES | 2021年 / 78卷 / 07期
关键词：
Immunotherapy; Leptin; Chemoresistance; BODY-MASS INDEX; MONOCYTE CHEMOATTRACTANT PROTEIN-1; EPITHELIAL-MESENCHYMAL TRANSITION; TUMOR-ASSOCIATED MACROPHAGES; ADIPOSE-TISSUE MACROPHAGES; NECROSIS-FACTOR-ALPHA; DIET-INDUCED OBESITY; BREAST-CANCER; INSULIN-RESISTANCE; LEPTIN RECEPTOR;
D O I：
10.1007/s00018-020-03752-z
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Obesity has been linked to an increased risk of and a worse prognosis for several types of cancer. A number of interrelated mediators contribute to obesity's pro-tumor effects, including chronic adipose inflammation and other perturbations of immune cell development and function. Here, we review studies examining the impact of obesity-induced immune dysfunction on cancer risk and progression. While the role of adipose tissue inflammation in obesity-associated cancer risk has been well characterized, the effects of obesity on immune cell infiltration and activity within the tumor microenvironment are not well studied. In this review, we aim to highlight the impact of both adipose-mediated inflammatory signaling and intratumoral immunosuppressive signaling in obesity-induced cancer risk, progression, and metastasis.
引用
收藏
页码：3423 / 3442
页数：20
相关论文
共 50 条
  • [1] The role of immune dysfunction in obesity-associated cancer risk, progression, and metastasis
    Aneesha Kulkarni
    Laura W. Bowers
    Cellular and Molecular Life Sciences, 2021, 78 : 3423 - 3442
  • [2] Obesity-associated Breast Cancer: Analysis of risk factors
    Engin, Atilla
    OBESITY AND LIPOTOXICITY, 2017, 960 : 571 - 606
  • [3] Exploiting the obesity-associated immune microenvironment for cancer therapeutics
    Desharnais, Lysanne
    Walsh, Logan A.
    Quail, Daniela F.
    PHARMACOLOGY & THERAPEUTICS, 2022, 229
  • [4] White adipocyte dysfunction and obesity-associated pathologies in humans
    Hagberg, Carolina E.
    Spalding, Kirsty L.
    NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2024, 25 (04) : 270 - 289
  • [5] Emerging mechanisms of obesity-associated immune dysfunction
    Shaikh, Saame Raza
    Beck, Melinda A.
    Alwarawrah, Yazan
    Maciver, Nancie J.
    NATURE REVIEWS ENDOCRINOLOGY, 2024, 20 (03) : 136 - 148
  • [6] Obesity-Associated Colorectal Cancer
    Gonzalez-Gutierrez, Lucia
    Motino, Omar
    Barriuso, Daniel
    de la Puente-aldea, Juan
    Alvarez-Frutos, Lucia
    Kroemer, Guido
    Palacios-Ramirez, Roberto
    Senovilla, Laura
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (16)
  • [7] Metformin as a Therapeutic Agent for Obesity-Associated Immune Dysfunction
    Rajeev, Devika
    MacIver, Nancie J.
    JOURNAL OF NUTRITION, 2024, 154 (08) : 2534 - 2542
  • [8] Obesity-Associated ECM Remodeling in Cancer Progression
    Li, Junyan
    Xu, Ren
    CANCERS, 2022, 14 (22)
  • [9] Obesity-associated cancer: an immunological perspective
    Conroy, Melissa J.
    Dunne, Margaret R.
    Donohoe, Claire L.
    Reynolds, John V.
    PROCEEDINGS OF THE NUTRITION SOCIETY, 2016, 75 (02) : 125 - 138
  • [10] Impact of obesity-associated myeloid-derived suppressor cells on cancer risk and progression (Review)
    Jimenez-Cortegana, Carlos
    Gutierrez-Garcia, Cristian
    Sanchez-Jimenez, Flora
    Vilarino-Garcia, Teresa
    Flores-Campos, Rocio
    Perez-Perez, Antonio
    Garnacho, Carmen
    Sanchez-Leon, Maria L.
    Garcia-Dominguez, Daniel J.
    Hontecillas-Prieto, Lourdes
    Palazon-Carrion, Natalia
    de la Cruz-Merino, Luis
    Sanchez-Margalet, Victor
    INTERNATIONAL JOURNAL OF ONCOLOGY, 2024, 65 (02)
12345