Dupilumab reduces need for systemic corticosteroid use, sinonasal surgery in patients with severe chronic rhinosinusitis with nasal polyps: Pooled results from the SINUS-24, SINUS-52 phase 3 studies

被引：0

作者：

Desrosiers, M. ^{[1
]}

Bachert, C. ^{[2
,3
]}

Hellings, P. W. ^{[4
]}

Hopkins, C. ^{[5
]}

Olze, H. ^{[6
]}

Han, J. K. ^{[7
]}

Lee, S. E. ^{[8
]}

Zhang, M. ^{[9
]}

Lu, X. ^{[9
]}

Amin, N. ^{[10
]}

Patel, N. ^{[9
]}

Graham, N. M. H. ^{[10
]}

Ruddy, M. ^{[10
]}

Staudinger, H. ^{[9
]}

Mannent, L. P. ^{[11
]}

机构：

[1] CRCHUM, Montreal, PQ, Canada

[2] Univ Ghent, Upper Airways Res Lab, Ghent, Belgium

[3] Karolinska Inst, Stockholm, Sweden

[4] Univ Hosp Leuven, Leuven, Belgium

[5] Guys & St Thomas Hosp, London, England

[6] Charite Univ Med Berlin, Dept Otorhinolaryngol Head & Neck Surg, Berlin, Germany

[7] Eastern Virginia Med Sch, Norfolk, VA 23501 USA

[8] Univ Pittsburgh, Med Ctr, Pittsburgh, PA USA

[9] Sanofi, Bridgewater, MA USA

[10] Regeneron Pharmaceut Inc, Tarrytown, NY USA

[11] Sanofi, Chilly Mazarin, France

来源：

ALLERGY | 2019年 / 74卷

关键词：

D O I：

暂无

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

PD0613

引用

页码：330 / 331

页数：2

共 42 条

[21] A Randomized Phase 3 Study, Sinus-52, Evaluating the Efficacy and Safety of Dupilumab in Patients with Severe Chronic Rhinosinusitis with Nasal Polyps
Bachert, Claus
Desrosiers, Martin
Mullol, Joaquim
Hellings, Peter W.
Cervin, Anders
Sher, Lawrence
Bosso, John V.
Lee, Stella E.
Maspero, Jorge F.
Fujieda, Shigeharu
Matsune, Shoji
Lu, Xin
Fan, Chunpeng
Draikiwicz, Steven
Amin, Nikhil
Kamat, Siddhesh
Khan, Asif
Pirozzi, Gianluca
Graham, Neil M. H.
Ruddy, Marcella
Staudinger, Heribert
Mannent, Leda P.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2019, 143 (02) : AB433 - AB433
[22] Dupilumab Improves Asthma Control as Assessed by Total and Individual Item Scores of the 6-Item Asthma Control Questionnaire in Patients with Severe Chronic Rhinosinusitis with Nasal Polyps and Comorbid Asthma: Pooled Results from the SINUS-24 and SINUS-52 Phase 3 Studies
Bachert, C.
Han, J. K.
Desrosiers, M.
Hellings, P. W.
Mao, X.
Zhang, M.
Amin, N.
Mannent, L. P.
Kamat, S.
Khan, A. H.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2020, 201
[23] Lung Function in Patients with Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) and Comorbid Asthma with Clinical Features of Chronic Obstructive Pulmonary Disease (COPD): Pooled Analysis of the Phase 3 SINUS-24 and SINUS-52 Studies
Maspero, J. F.
Bachert, C.
Ortiz, B.
Patel, N.
Mannent, L. P.
Daizadeh, N.
Hardin, M.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2020, 201
[24] Dupilumab improves outcomes in patients with chronic rhinosinusitis with nasal polyps irrespective of gender: results from the SINUS-52 trial
Fokkens, Wytske J.
Bachert, Claus
Hopkins, Claire
Marglani, Osama
Praestgaard, Amy
Nash, Scott
Deniz, Yamo
Rowe, Paul J.
Sacks, Harry
Jacob-Nara, Juby A.
CLINICAL & TRANSLATIONAL IMMUNOLOGY, 2024, 13 (06)
[25] Dupilumab Reduces Blood, Urine, and Nasal Biomarkers of Type 2 Inflammation in Patients With Chronic Rhinosinusitis With Nasal Polyps in the Phase 3 SINUS-52 Trial
Bachert, Claus
Cho, Seong
Laidlaw, Tanya
Swanson, Brian
Harel, Sivan
Mannent, Leda
Amin, Nikhil
Jagerschmidt, Alexandre
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2020, 145 (02) : AB185 - AB185
[26] Effect of Dupilumab on Type 2 Biomarkers in Chronic Rhinosinusitis With Nasal Polyps: SINUS-52 Study Results
Bachert, Claus
Laidlaw, Tanya M.
Cho, Seong H.
Mullol, Joaquim
Swanson, Brian N.
Naimi, Souad
Classe, Marion
Harel, Sivan
Jagerschmidt, Alexandre
Laws, Elizabeth
Ruddy, Marcella
Praestgaard, Amy
Amin, Nikhil
Mannent, Leda P.
ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY, 2023, : 1649 - 1661
[27] Dupilumab efficacy in chronic rhinosinusitis with nasal polyps from SINUS-52 is unaffected by eosinophilic status
Fujieda, Shigeharu
Matsune, Shoji
Takeno, Sachio
Ohta, Nobuo
Asako, Mikiya
Bachert, Claus
Inoue, Tomoyuki
Takahashi, Yoshinori
Fujita, Hiroyuki
Deniz, Yamo
Rowe, Paul
Ortiz, Benjamin
Li, Yongtao
Mannent, Leda P.
ALLERGY, 2022, 77 (01) : 186 - 196
[28] Responder analysis to demonstrate the effect of targeting type 2 inflammatory mechanisms with dupilumab across objective and patient-reported endpoints for patients with severe chronic rhinosinusitis with nasal polyps in the SINUS-24 and SINUS-52 studies
Bachert, Claus
Peters, Anju T.
Heffler, Enrico
Han, Joseph K.
Olze, Heidi
Pfaar, Oliver
Chuang, Chien-Chia
Rout, Raj
Attre, Richa
Goga, Ledia
Jacob-Nara, Juby A.
Rowe, Paul J.
Deniz, Yamo
Chen, Zhen
Kamat, Siddhesh
Siddiqui, Shahid
CLINICAL AND EXPERIMENTAL ALLERGY, 2022, 52 (02): : 244 - 249
[29] Clinical Efficacy among Patients with Chronic Rhinosinusitis with Nasal Polyps and Clinical Features of Obstructive Lung Disease: Post Hoc Analysis of the Phase III SINUS-24 and SINUS-52 Studies
Maspero, Jorge F.
Bachert, Claus
Martinez, Fernando J.
Hanania, Nicola A.
Ortiz, Benjamin
Patel, Naimish
Mannent, Leda P.
Praestgaard, Amy
Pandit-Abid, Nami
Siddiqui, Shahid
Hardin, Megan
JOURNAL OF ASTHMA AND ALLERGY, 2023, 16 : 333 - 342
[30] Dupilumab (DPL) Improves Upper and Lower Airway Outcomes in Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) with Nonsteroidal Anti-inflammatory Drug-Exacerbated Respiratory Disease (NSAID-ERD): Pooled Results From SINUS-24, SINUS-52 Phase 3 Trials
Laidlaw, Tanya M.
Mullol, Joaquim
Canonica, G. Walter
Bachert, Claus
Han, Joseph K.
Zhang, Mei
Lu, Xin
Patel, Naimish
Graham, Neil Mh
Staudinger, Heribert
Mannent, Leda P.
Amin, Nikhil
EUROPEAN RESPIRATORY JOURNAL, 2019, 54

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