Pervasive lncRNA binding by epigenetic modifying complexes - The challenges ahead

被引:19
作者
Betancur, Juan G. [1 ]
机构
[1] RIKEN IMS, Lab Dev Genet, Tsurumi Ku, Yokohama, Kanagawa 2300045, Japan
来源
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS | 2016年 / 1859卷 / 01期
关键词
lncRNA; Polycomb; RNA-binding protein; DNA methylation; Chromatin remodeling; Histone modification; LONG NONCODING RNA; POLYCOMB REPRESSIVE COMPLEX; INACTIVE X-CHROMOSOME; HISTONE METHYLTRANSFERASE COMPLEX; SELECTIVE 2'-HYDROXYL ACYLATION; SINGLE NUCLEOTIDE RESOLUTION; H3; LYSINE-27; METHYLATION; CORONARY-ARTERY-DISEASE; PRIMER EXTENSION SHAPE; DNA METHYLATION;
D O I
10.1016/j.bbagrm.2015.10.009
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Epigenetic modifying factors are fundamental regulators of chromatin structure and gene expression during development and differentiation through the induction of chemical modifications on histones, DNA or via remodeling of the chromatin structure. Protein complexes involved in these three processes contain non canonical RNA-binding components that interact with long non-coding RNAs, in many cases in the absence of any sequence or structural signatures. However, there is growing evidence of the role of such protein-lncRNA interactions in the regulation of the epigenetic landscape in vivo. This review summarizes the growing number of epigenetic modifying factors described to interact with lncRNAs in mouse and human, and then discusses the challenges that lay ahead in understanding lncRNAs as part of the intricate networks of epigenetic regulation. A combination of protein and RNA-centric approaches is required for this purpose. This article is part of a Special Issue entitled: Clues to long noncoding RNA taxonomy, edited by Dr. Tetsuro Hirose and Dr. Shinichi Nakagawa. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码:93 / 101
页数:9
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