Intraseptal infusions of 8-OH-DPAT in the rat impairs water-maze performances: effects on memory or anxiety?

被引：29

作者：

Bertrand, F ^{[1
]}

Lehmann, O ^{[1
]}

Lazarus, C ^{[1
]}

Jeltsch, H ^{[1
]}

Cassel, JC ^{[1
]}

机构：

[1] Univ Strasbourg 1, Lab Neurosci Comportementaes & Cognit, UMR 7521 CNRS, F-67000 Strasbourg, France

来源：

NEUROSCIENCE LETTERS | 2000年 / 279卷 / 01期

关键词：

rat; water maze; spatial reference memory; anxiety; 5-HT1A receptor; medial septum;

D O I：

10.1016/S0304-3940(99)00948-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In the rat, 5-HT1A receptors are found on medial septal cholinergic neurons. The effects of intraseptal infusions of the 5-HT1A receptor agonist 8-OH-DPAT (8-hydroxy-2-(di-n-propyl-amino)-tetralin) were assessed on reference memory performances in a water maze. Compared with vehicle infusions, 0.5 and 4 mu g of 8-OH-DPAT significantly impaired (but did not prevent) acquisition of the task and probe-trial performances. The results suggest that activation of 5-TH1A receptors in the (medial) septal area impairs spatial learning, perhaps directly by reducing the hippocampal cholinergic;onus, or indirectly by an effect on anxiety. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：45 / 48

页数：4

共 20 条

[1]

Acsády L, 1996, ACTA BIOL HUNG, V47, P9

[2] STIMULATION OF 5-HT(1A) RECEPTORS IN THE DORSAL HIPPOCAMPUS IMPAIRS ACQUISITION AND PERFORMANCE OF A SPATIAL TASK IN A WATER MAZE [J].