Germline mutation of microRNA-125a is associated with breast cancer

被引：81

作者：

Li, W. ^{[1
]}

Duan, R. ^{[1
]}

Kooy, F. ^{[2
]}

Sherman, S. L. ^{[1
]}

Zhou, W. ^{[3
]}

Jin, P. ^{[1
]}

机构：

[1] Emory Univ, Sch Med, Dept Human Genet, Atlanta, GA 30322 USA

[2] Univ Antwerp, Dept Med Genet, B-2020 Antwerp, Belgium

[3] Emory Univ, Sch Med, Winship Canc Inst, Dept Hematol & Oncol, Atlanta, GA 30322 USA

来源：

JOURNAL OF MEDICAL GENETICS | 2009年 / 46卷 / 05期

关键词：

DISTANT RELAPSE; EXPRESSION; MIR-125A; PANEL;

D O I：

10.1136/jmg.2008.063123

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

MicroRNAs (miRNAs) are small non-coding RNAs that inhibit expression of specific target genes at the posttranscriptional level. MiRNAs are often found to be misregulated in human cancer, and they can act as either potent oncogenes or tumour suppressor genes. Here we show that a germline mutation in mature miR-125a is highly associated with breast cancer tumorigenesis, suggesting that miR-125a is likely to function as a tumour suppressor gene in human cancer.

引用

页码：358 / 360

页数：3

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