A novel and highly efficient synthesis of gem-difluorocyclopropanes

被引：107

作者：

Tian, F

Kruger, V

Bautista, O

Duan, JX

Li, AR

Dolbier, WR ^{[1
]}

Chen, QY

机构：

[1] Univ Florida, Dept Chem, Gainesville, FL 32611 USA

[2] Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 04期

关键词：

D O I：

10.1021/ol0055622

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A new and highly versatile source of difluorocarbene is reported. Trimethylsilyl fluorosulfonyldifluoroacetate (TFDA) undergoes decomposition in the presence of catalytic fluoride to form difluorocarbene under conditions that allow its addition to relatively electron deficient alkenes in high yield. For example, unprecedented CF2: addition to n-butyl acrylate proceeded in 73% yield.

引用

页码：563 / 564

页数：2

共 11 条

[1]

BIRCHALL JM, 1960, P CHEM SOC LONDON, P81

[2] Fluorinated carbenes [J].