Determination of six lignans in Schisandra chinensis (Turcz.) Baill. Fruits and related Chinese multiherb remedies by HPLC

被引：50

作者：

Zhang, Hai ^{[2
]}

Zhang, Guoqing ^{[2
]}

Zhu, Zhenyu ^{[1
]}

Zhao, Liang ^{[2
]}

Fei, Yang ^{[2
]}

Jing, Jing ^{[1
]}

Chai, Yifeng ^{[1
]}

机构：

[1] Second Mil Med Univ, Sch Pharm, Shanghai 200433, Peoples R China

[2] Eastern Hepatobiliary Surg Hosp, Dept Pharm, Shanghai 200438, Peoples R China

来源：

FOOD CHEMISTRY | 2009年 / 115卷 / 02期

关键词：

Schisandra chinensis; Lignans; High-performance liquid chromatography; CAPILLARY ELECTROCHROMATOGRAPHY; LIQUID-CHROMATOGRAPHY; MASS-SPECTROMETRY; CONSTITUENTS; MEDICINES;

D O I：

10.1016/j.foodchem.2008.12.010

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A simple, rapid and specific HPLC method was established for simultaneous determination of six major lignans in Schisandra chinensis and related Chinese multiherb remedies (CMRs) containing this herb. The six lignans were successfully separated on a C-18 column by gradient elution using acetonitrile and water as the mobile phase, and detection wavelength was set at 225 rim. The method was validated through the following performance criteria: linearity, precision, repeatability, stability, accuracy, limit of detection (LOD) and quantification (LOQ). This assay was successfully used for determination of six lignans in 10 raw herbs collected from different regions in China and five Chinese multiherb remedies. Significant variations were demonstrated in the contents of six compounds in these samples. This HPLC method established is suitable for routine quantitative analysis of S. chinensis and multiherb remedies containing this herb. Crown Copyright (C) 2008 Published by Elsevier Ltd. All rights reserved.

引用

页码：735 / 739

页数：5

共 17 条

[1] Inhibitory effect of the Korean herbal medicine, Dae-Jo-Whan, on platelet-activating factor-induced platelet aggregation
Chang, GT
Kang, SK
Kim, JH
Chung, KH
Chang, YC
Kim, CH
[J]. JOURNAL OF ETHNOPHARMACOLOGY, 2005, 102 (03) : 430 - 439
[2] Separation and determination of active components in Schisandra chinensis Baill. and its medicinal preparations by non-aqueous capillary electrophoresis
Chen, AJ
Li, CH
Gao, WH
Hu, ZD
Chen, XG
[J]. BIOMEDICAL CHROMATOGRAPHY, 2005, 19 (07) : 481 - 487
[3] Validation of a method for the simultaneous determination of four schisandra lignans in the raw herb and commercial dried aqueous extracts of Schisandra chinensis (Wu Wei Zi) by RP-LC with DAD
Halstead, C. W.
Lee, S.
Khoo, C. S.
Hennell, J. R.
Bensoussan, A.
[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2007, 45 (01) : 30 - 37
[4] Schisandra chinensis (Turcz.) Baill
Hancke, JL
Burgos, RA
Ahumada, F
[J]. FITOTERAPIA, 1999, 70 (05) : 451 - 471
[5] Analysis of lignan constituents from Schisandra chinensis by liquid chromatography-electrospray mass spectrometry
He, XG
Lian, LZ
Lin, LZ
[J]. JOURNAL OF CHROMATOGRAPHY A, 1997, 757 (1-2) : 81 - 87
[6] Studies on lignan constituents from Schisandra chinensis (Turcz.) Baill. fruits using high-performance liquid chromatography/electrospray ionization multiple-stage tandem mass spectrometry
Huang, Xin
Song, Fengrui
Liu, Zhiqiang
Liu, Shuying
[J]. JOURNAL OF MASS SPECTROMETRY, 2007, 42 (09): : 1148 - 1161
[7] The crucial antioxidant action of schisandrin B in protecting against carbon tetrachloride hepatotoxicity in mice: A comparative study with butylated hydroxytoluene
Ip, SP
Ko, KM
[J]. BIOCHEMICAL PHARMACOLOGY, 1996, 52 (11) : 1687 - 1693
[8] JIAN G, 2007, BIOMEDICAL CHROMATOG, V21, P299
[9] Application of capillary electrochromatography using macroporous polyacrylamide columns for the analysis of lignans from seeds of Schisandra chinensis
Kvasnicková, L
Glatz, Z
Sterbová, H
Kahle, V
Slanina, J
Musil, P
[J]. JOURNAL OF CHROMATOGRAPHY A, 2001, 916 (1-2) : 265 - 271
[10] Analysis of volatile fractions of Schisandra chinensis (Turcz.) baill. using GC-MS and chemometric resolution
Li, XN
Cui, H
Song, YQ
Liang, YZ
Chau, FT
[J]. PHYTOCHEMICAL ANALYSIS, 2003, 14 (01) : 23 - 33

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