Vitamin D and Cognition: An Update of the Current Evidence

被引:47
作者
Anastasiou, Costas A. [1 ]
Yannakoulia, Mary [1 ]
Scarmeas, Nikolaos [2 ,3 ]
机构
[1] Harokopio Univ, Dept Nutr & Dietet, Athens, Greece
[2] Columbia Univ, Gertrude H Sergievsky Ctr, Dept Neurol, Taub Inst Res Alzheimers Dis & Aging Brain, New York, NY 10027 USA
[3] Univ Athens, Dept Social Med Psychiat & Neurol, Athens, Greece
关键词
Alzheimer's disease; amyloid; cholecalciferol; cognition; dementia; vitamin D; CIRCULATING 25-HYDROXYVITAMIN D; AMYLOID-BETA; ALZHEIMERS-DISEASE; 1-ALPHA; 25-DIHYDROXYVITAMIN D-3; D SUPPLEMENTATION; D DEFICIENCY; D-RECEPTOR; 1,25-DIHYDROXYVITAMIN D-3; DEPRESSIVE SYMPTOMS; CALCIUM-CHANNEL;
D O I
10.3233/JAD-132636
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The active form vitamin D is a seco-steroid with multiple neurotrophic and neuroprotective functions in the central nervous system. Robust evidence from studies in animals suggests that vitamin D deficiency may impair brain physiological functioning causing anatomical and behavioral adverse effects. On the other hand, vitamin D has been found to be protective against biological processes associated with Alzheimer's disease and cognition, including amyloid-beta deposition, inflammation, calcium homeostasis, and corticosteroid-induced perturbations in cortical areas and the hippocampus. Human studies that examined the relationship between vitamin D status and cognitive function have provided inconclusive results. The majority of cross-sectional and longitudinal studies suggest a potentially protective association, whereas results from clinical trials are mostly negative, or at best, controversial. We review these studies in humans, with particular emphasis on randomized and observational prospective ones.
引用
收藏
页码:S71 / S80
页数:10
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