Shedding Light on Extracellular Vesicle Biogenesis and Bioengineering

被引：262
作者：
Teng, Fei [1 ]
Fussenegger, Martin [1 ,2 ]
机构：
[1] Swiss Fed Inst Technol, Dept Biosyst Sci & Engn, Mattenstr 26, CH-4058 Basel, Switzerland
[2] Univ Basel, Fac Sci, Mattenstr 26, CH-4058 Basel, Switzerland
来源：
ADVANCED SCIENCE | 2021年 / 8卷 / 01期
基金：
欧洲研究理事会;
关键词：
bioengineering; delivery systems; exosomes; extracellular vesicles; microvesicles; MULTIVESICULAR BODY BIOGENESIS; ENDOSOME-ASSOCIATED COMPLEX; ESCRT-III; EXOSOME SECRETION; UBIQUITIN RECOGNITION; TRANSFERRIN RECEPTOR; MEMBRANE SCISSION; INTERCELLULAR TRANSFER; LYSOSOMAL DEGRADATION; ACID SPHINGOMYELINASE;
D O I：
10.1002/advs.202003505
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Extracellular vesicles (EVs) are biocompatible, nano-sized secreted vesicles containing many types of biomolecules, including proteins, RNAs, DNAs, lipids, and metabolites. Their low immunogenicity and ability to functionally modify recipient cells by transferring diverse bioactive constituents make them an excellent candidate for a next-generation drug delivery system. Here, the recent advances in EV biology and emerging strategies of EV bioengineering are summarized, and the prospects for clinical translation of bioengineered EVs and the challenges to be overcome are discussed.
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页数：17
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