Low Serum Amylase is Associated with Gestational Diabetes Mellitus in Chinese Pregnant Women

被引：6

作者：

Zheng, Ruoheng ^{[1
]}

Zhang, Juanwen ^{[2
]}

Zhao, Ying ^{[2
]}

Zheng, Nengneng ^{[3
]}

机构：

[1] Zhejiang Med Coll, Dept Clin Med, Hangzhou 310053, Zhejiang, Peoples R China

[2] Zhejiang Univ, Coll Med, Affiliated Hosp 1, Dept Lab Med, Hangzhou 310003, Zhejiang, Peoples R China

[3] Tongde Hosp Zhejiang Prov, Dept Gynecol & Obstet, 234 Gucui Rd, Hangzhou 310012, Zhejiang, Peoples R China

来源：

CLINICAL LABORATORY | 2015年 / 61卷 / 10期

关键词：

gestational diabetes mellitus; metabolic syndrome; insulin resistance; amylase; METABOLIC SYNDROME; INSULIN-RESISTANCE; RISK; DIAGNOSIS; GLUCOSE; PREVENTION; MANAGEMENT; PANCREAS; HISTORY; DISEASE;

D O I：

10.7754/Clin.Lab.2015.150129

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Background: The association between low serum amylase levels and type 2 diabetes mellitus and metabolic syndrome has been clearly disclosed. However, the relationship between serum amylase levels and gestational diabetes mellitus (GDM) has not been extensively studied. This study aimed to assess the association of serum amylase with GDM. Methods: A cross-sectional study was performed among 878 Chinese pregnant women who underwent detailed prenatal visits in Hangzhou, China. Results: A total of 108 (12.30%) subjects fulfilled the diagnostic criteria of GDM. Patients with GDM had significantly lower levels of serum amylase than those without GDM. The prevalence rate of GDM decreased across serum amylase increasing tertiles (p for trend < 0.001). Correlation analysis showed that serum amylase level was negatively correlated with fasting plasma glucose, 1hPG, 2hPG, HOMA-IR, triglyceride, free fatty acid, and thyroid stimulating hormone (all with p < 0.05). Multiple logistic regression showed that low serum amylase level predicted increased risk of GDM. Conclusions: Our findings suggest that low serum amylase level is significantly associated with increased risk of GDM.

引用

页码：1423 / 1428

页数：6

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