Four new compounds from Imperata cylindrica

被引：17

作者：

Liu, Xuan ^{[1
]}

Zhang, Bin-Feng ^{[2
,3
]}

Yang, Li ^{[2
,3
]}

Chou, Gui-Xin ^{[2
,3
]}

Wang, Zheng-Tao ^{[1
,2
,3
]}

机构：

[1] China Pharmaceut Univ, Dept Pharmacognosy, Nanjing 210038, Jiangsu, Peoples R China

[2] Shanghai R&D Ctr Standardizat Chinese Med, Shanghai 201203, Peoples R China

[3] Shanghai Univ Tradit Chinese Med, Inst Chinese Mat Med, Key Lab Standardizat Chinese Med, Minist Educ, Shanghai 201203, Peoples R China

来源：

JOURNAL OF NATURAL MEDICINES | 2014年 / 68卷 / 02期

关键词：

Imperata cylindrica; Chemical constituents; Structural elucidation; Calcium assay; Anti-inflammatory activity; LIGNAN;

D O I：

10.1007/s11418-013-0793-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four new compounds, impecylone (1), deacetylimpecyloside (2), seguinoside K 4-methylether (3) and impecylenolide (4), were isolated from Imperata cylindrica along with two known compounds, impecyloside (5) and seguinoside K (6). Their structures were elucidated mainly by spectroscopic analyses including 1D- and 2D-NMR techniques, and the absolute configuration of 1 was confirmed by X-ray diffraction analysis. In calcium assay, the result indicated that compounds 1, 2, 4 and 5 cannot obviously inhibit the calcium peak value compared with the negative control, and suggested that the four compounds could not have anti-inflammatory activity.

引用

页码：295 / 301

页数：7

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