Estimations of intrinsic and extrinsic noise in models of nonlinear genetic networks

被引：78

作者：

Scott, Matthew ^{[1
]}

Ingalls, Brian

Kaern, Mads

机构：

[1] Univ Calif San Diego, Dept Phys, Ctr Theoret Biol Phys, La Jolla, CA 92093 USA

[2] Univ Waterloo, Dept Appl Math, Waterloo, ON N2L 3G1, Canada

[3] Univ Ottawa, Dept Phys, Dept Cellular & Mol Med, Ottawa Inst Syst Biol, Ottawa, ON K1H 8M5, Canada

来源：

CHAOS | 2006年 / 16卷 / 02期

关键词：

D O I：

10.1063/1.2211787

中图分类号：

O29 [应用数学];

学科分类号：

070104 ;

摘要：

We discuss two methods that can be used to estimate the impact of internal and external variability on nonlinear systems, and demonstrate their utility by comparing two experimentally implemented oscillatory genetic networks with different designs. The methods allow for rapid estimations of intrinsic and extrinsic noise and should prove useful in the analysis of natural genetic networks and when constructing synthetic gene regulatory systems.

引用

页数：15

共 71 条

[21] Stochastic gene expression in a single cell [J].

Elowitz, MB ;

Levine, AJ ;

Siggia, ED ;

Swain, PS .

SCIENCE, 2002, 297 (5584) :1183-1186

[22] A synthetic oscillatory network of transcriptional regulators [J].

Elowitz, MB ;

Leibler, S .

NATURE, 2000, 403 (6767) :335-338

[23] Precise temporal modulation in the response of the SOS DNA repair network in individual bacteria [J].

Friedman, N ;

Vardi, S ;

Ronen, M ;

Alon, U ;

Stavans, J .

PLOS BIOLOGY, 2005, 3 (07) :1261-1268

[24] The correlation time of mesoscopic chemical clocks [J].

Gaspard, P .

JOURNAL OF CHEMICAL PHYSICS, 2002, 117 (19) :8905-8916

[25] The chemical Langevin equation [J].

Gillespie, DT .

JOURNAL OF CHEMICAL PHYSICS, 2000, 113 (01) :297-306

[26] EXACT STOCHASTIC SIMULATION OF COUPLED CHEMICAL-REACTIONS [J].

GILLESPIE, DT .

JOURNAL OF PHYSICAL CHEMISTRY, 1977, 81 (25) :2340-2361

[27] Robustness of circadian rhythms with respect to molecular noise [J].

Gonze, D ;

Halloy, J ;

Goldbeter, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (02) :673-678

[28] Sensitivity analysis of discrete stochastic systems [J].

Gunawan, R ;

Cao, Y ;

Petzold, L ;

Doyle, FJ .

BIOPHYSICAL JOURNAL, 2005, 88 (04) :2530-2540

[29] Stochastic reaction-diffusion simulation with MesoRD [J].

Hattne, J ;

Fange, D ;

Elf, J .

BIOINFORMATICS, 2005, 21 (12) :2923-2924

[30]

Heinrich R., 1996, REGULATION CELLULAR, DOI DOI 10.1007/978-1-4613-1161-4

← 1 2 3 4 5 6 7 8 →