Picornavirus uncoating

被引:48
作者
Smyth, MS
Martin, JH
机构
[1] Mol Struct Solut, Wolverhampton WV1 1SB, England
[2] Wolverhampton Univ, Sch Appl Sci, Div Biomed Sci, Wolverhampton WV1 1SB, England
来源
JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY | 2002年 / 55卷 / 04期
关键词
D O I
10.1136/mp.55.4.214
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Recently, much has been learned about the molecular mechanisms involved in the pathogenesis of picornaviruses. This has been accelerated by the solving of the crystal structures of many members of this virus family. However, one stage of the virus life cycle remains poorly understood: uncoating. How do these simple but efficient pathogens protect their RNA genomes with a stable protein shell and yet manage to uncoat this genome at precisely the right time during infection? The purpose of this article is to review the current state of knowledge and the most recent theories that attempt to answer this question. The review is based extensively on structural data but also makes reference to the wealth of biochemical information on the topic.
引用
收藏
页码:214 / 219
页数:6
相关论文
共 44 条
[1]   THE 3-DIMENSIONAL STRUCTURE OF FOOT-AND-MOUTH-DISEASE VIRUS AT 2.9-A RESOLUTION [J].
ACHARYA, R ;
FRY, E ;
STUART, D ;
FOX, G ;
ROWLANDS, D ;
BROWN, F .
NATURE, 1989, 337 (6209) :709-716
[2]   ANALYSIS OF THE STRUCTURE OF A COMMON COLD VIRUS, HUMAN RHINOVIRUS-14, REFINED AT A RESOLUTION OF 3.0-A [J].
ARNOLD, E ;
ROSSMANN, MG .
JOURNAL OF MOLECULAR BIOLOGY, 1990, 211 (04) :763-801
[3]   Isolation of a common receptor for coxsackie B viruses and adenoviruses 2 and 5 [J].
Bergelson, JM ;
Cunningham, JA ;
Droguett, G ;
KurtJones, EA ;
Krithivas, A ;
Hong, JS ;
Horwitz, MS ;
Crowell, RL ;
Finberg, RW .
SCIENCE, 1997, 275 (5304) :1320-1323
[4]   COXSACKIEVIRUS B3 ADAPTED TO GROWTH IN RD CELLS BINDS TO DECAY-ACCELERATING FACTOR (CD55) [J].
BERGELSON, JM ;
MOHANTY, JG ;
CROWELL, RL ;
JOHN, NFS ;
LUBLIN, DM ;
FINBERG, RW .
JOURNAL OF VIROLOGY, 1995, 69 (03) :1903-1906
[5]   THE NUCLEOTIDE-SEQUENCE OF COXSACKIEVIRUS-A9 - IMPLICATIONS FOR RECEPTOR-BINDING AND ENTEROVIRUS CLASSIFICATION [J].
CHANG, KH ;
AUVINEN, P ;
HYYPIA, T ;
STANWAY, G .
JOURNAL OF GENERAL VIROLOGY, 1989, 70 :3269-3280
[6]  
CHENG RH, 1994, STRUCTURE, V2, P271
[7]   MYRISTYLATION OF PICORNAVIRUS CAPSID PROTEIN VP4 AND ITS STRUCTURAL SIGNIFICANCE [J].
CHOW, M ;
NEWMAN, JFE ;
FILMAN, D ;
HOGLE, JM ;
ROWLANDS, DJ ;
BROWN, F .
NATURE, 1987, 327 (6122) :482-486
[8]   SPECIFIC ALTERATIONS OF COXSACKIEVIRUS B3 ELUTED FROM HELA CELLS [J].
CROWELL, RL ;
PHILIPSON, L .
JOURNAL OF VIROLOGY, 1971, 8 (04) :509-+
[9]   VIRAL-RNA MODULATES THE ACID SENSITIVITY OF FOOT-AND-MOUTH-DISEASE VIRUS CAPSIDS [J].
CURRY, S ;
ABRAMS, CC ;
FRY, E ;
CROWTHER, JC ;
BELSHAM, GJ ;
STUART, DI ;
KING, AMQ .
JOURNAL OF VIROLOGY, 1995, 69 (01) :430-438
[10]   STUDIES ON INVITRO UNCOATING OF POLIOVIRUS .1. CHARACTERIZATION OF MODIFYING FACTOR AND MODIFYING REACTION [J].
DESENA, J ;
MANDEL, B .
VIROLOGY, 1976, 70 (02) :470-483