Effect of immunotherapy on the response of TICLs to solid tumour invasion

被引：7

作者：

Mambili-Mamboundou, Hermane ^{[1
]}

Sibanda, Precious ^{[1
]}

Malinzi, Joseph ^{[1
]}

机构：

[1] Univ Kwazulu Natal, Sch Math Stat & Comp Sci, ZA-3209 Pietermaritzburg, South Africa

来源：

MATHEMATICAL BIOSCIENCES | 2014年 / 249卷

关键词：

Resting cells; Cancer dormancy; Tumour-immune interactione TICLs-tumour; interactions; Immunotherapy; MIGRATION; CANCER;

D O I：

10.1016/j.mbs.2014.01.002

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

There is clinical evidence that some people have lived with a benign tumour for their entire life time. This is explained by cancer dormancy which is attributed to the interaction of tumour infiltrating cytotoxic lymphocytes (TICLs) with tumour cells. We present two mathematical models to study the mechanism of interaction of TICLs with tumour cells, with and without clinical intervention. Stability analysis and numerical simulations of the models reveal the existence of a stable tumour dormant state. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：52 / 59

页数：8

共 20 条

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