Transforming growth factor-β enhances human T-cell leukemia virus type I infection

被引：20
|
作者：
Moriuchi, M
Moriuchi, H
机构：
[1] Nagasaki Univ, Sch Med, Dept Pediat, Nagasaki 8528501, Japan
[2] Nagasaki Univ, Grad Sch Med Sci, Dept Mol Microbiol & Immunol, Div Med Virol, Nagasaki 852, Japan
来源：
JOURNAL OF MEDICAL VIROLOGY | 2002年 / 67卷 / 03期
关键词：
breast milk; semen; transcription; long terminal repeat;
D O I：
10.1002/jmv.10074
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Human T-cell leukemia virus type I (HTLV-I), the causative agent of adult T-cell leukemia/lymphoma, is transmitted vertically by breast milk and sexually by semen. The transforming growth factor-beta (TGF-beta), a pleiotropic cytokine that is abundant in breast milk and semen, facilitates replication of HTLV-I in lymphocytes derived from asymptomatic HTLV-I carriers and transmission to cord blood lymphocytes in vitro. Transient expression assays revealed that TGF-beta can transactivate HTLV-I long terminal repeat promoter. These results suggest that TGF-beta may play a role in replication and transmission of HTLV-I. J. Med. Virol. 67:427-430,2002. (C) 2002 Wiley-Liss, Inc.
引用
收藏
页码：427 / 430
页数：4
相关论文
共 50 条
  • [41] Human T-lymphotropic virus type I provirus and T-cell prolymphocytic leukemia
    Kojima, K
    Hara, M
    Sawada, T
    Miyata, A
    Saito, H
    Matsuo, Y
    Yasukawa, M
    Fujita, S
    Harada, M
    LEUKEMIA & LYMPHOMA, 2000, 38 (3-4) : 381 - 386
  • [42] Human T lymphotropic virus type-I and adult T-cell leukemia in Japan
    Yamaguchi, K
    Watanabe, T
    INTERNATIONAL JOURNAL OF HEMATOLOGY, 2002, 76 (Suppl 2) : 240 - 245
  • [43] Expression of transforming growth factor-β type I receptor and transforming growth factor-β type II receptor in rat retina
    Shen, Wei
    Liu, Lin
    INTERNATIONAL JOURNAL OF OPHTHALMOLOGY, 2009, 2 (03) : 204 - 206
  • [44] Human T lymphotropic virus type-I and adult T-cell leukemia in Japan
    Kazunari Yamaguchi
    Toshiki Watanabe
    International Journal of Hematology, 2002, 76 : 240 - 245
  • [45] Risk of Human T-Cell Leukemia Virus Type 1 Infection in Kidney Transplantation
    Yamauchi, Junji
    Yamano, Yoshihisa
    Yuzawa, Kenji
    NEW ENGLAND JOURNAL OF MEDICINE, 2019, 380 (03): : 296 - 298
  • [46] ANGIOCENTRIC T-CELL LYMPHOMA ASSOCIATED WITH HUMAN T-CELL LYMPHOTROPIC VIRUS TYPE-I INFECTION
    MCNUTT, NS
    SMOLLER, BR
    KLINE, M
    COHEN, SR
    HSU, A
    SALTZ, L
    CASH, K
    SAFAI, B
    ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE, 1990, 114 (02) : 170 - 175
  • [47] Neuraminidase enhances the initial steps of human T-cell leukemia virus type 1 replication
    Tanaka, Masakazu
    Sun, Binlian
    Tezuka, Kenta
    Fujisawa, Jun-ichi
    Tanaka, Yuetsu
    Hoshino, Hiroo
    Miwa, Masanao
    MICROBES AND INFECTION, 2010, 12 (02) : 119 - 125
  • [48] Transforming growth factor-β signaling is constantly shaping memory T-cell population
    Ma, Chaoyu
    Zhang, Nu
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 112 (35) : 11013 - 11017
  • [49] Pathogenesis and treatment of human T-cell leukemia virus infection
    Lee Ratner
    Immunologic Research, 2005, 32 : 217 - 223
  • [50] KAPOSIS-SARCOMA IN HUMAN T-CELL LEUKEMIA-VIRUS TYPE-I-ASSOCIATED ADULT T-CELL LEUKEMIA
    GREENBERG, SJ
    JAFFE, ES
    EHRLICH, GD
    KORMAN, NJ
    POIESZ, BJ
    WALDMANN, TA
    BLOOD, 1990, 76 (05) : 971 - 976
12345