Transforming growth factor-β enhances human T-cell leukemia virus type I infection

被引：20
|
作者：
Moriuchi, M
Moriuchi, H
机构：
[1] Nagasaki Univ, Sch Med, Dept Pediat, Nagasaki 8528501, Japan
[2] Nagasaki Univ, Grad Sch Med Sci, Dept Mol Microbiol & Immunol, Div Med Virol, Nagasaki 852, Japan
来源：
JOURNAL OF MEDICAL VIROLOGY | 2002年 / 67卷 / 03期
关键词：
breast milk; semen; transcription; long terminal repeat;
D O I：
10.1002/jmv.10074
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Human T-cell leukemia virus type I (HTLV-I), the causative agent of adult T-cell leukemia/lymphoma, is transmitted vertically by breast milk and sexually by semen. The transforming growth factor-beta (TGF-beta), a pleiotropic cytokine that is abundant in breast milk and semen, facilitates replication of HTLV-I in lymphocytes derived from asymptomatic HTLV-I carriers and transmission to cord blood lymphocytes in vitro. Transient expression assays revealed that TGF-beta can transactivate HTLV-I long terminal repeat promoter. These results suggest that TGF-beta may play a role in replication and transmission of HTLV-I. J. Med. Virol. 67:427-430,2002. (C) 2002 Wiley-Liss, Inc.
引用
收藏
页码：427 / 430
页数：4
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