Effects of cytotoxic nucleus accumbens lesions on instrumental conditioning in rats

被引:92
作者
de Borchgrave, R
Rawlins, JNP
Dickinson, A
Balleine, BW
机构
[1] Univ Oxford, Dept Expt Psychol, Oxford OX1 3UD, England
[2] Univ Cambridge, Dept Expt Psychol, Cambridge, England
[3] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90095 USA
基金
英国生物技术与生命科学研究理事会; 英国惠康基金;
关键词
nucleus accumbens; systemic d-amphetamine; instrumental conditioning; outcome devaluation; conditioned reinforcement; Pavlovian-instrumental transfer;
D O I
10.1007/s00221-002-1031-y
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
In two experiments the involvement of the nucleus accumbens in instrumental conditioning was investigated using rats as subjects. In experiment 1, extensive bilateral cytotoxic lesions of the nucleus accumbens mildly suppressed instrumental responding reinforced with food, but had no detectable effect on the sensitivity of the rats' performance either to outcome devaluation or to degradation of the instrumental contingency. In experiment 2, restricted accumbens lesions reliably attenuated the excitatory effect of systemically administered d-amphetamine on lever pressing for a conditioned reinforcer, and completely abolished Pavlovian-instrumental transfer. Taken together these results give a picture of the involvement of the rat nucleus accumbens in instrumental conditioning. They support the widely held theory that the nucleus accumbens mediates the excitatory effects of appetitively conditioned Pavlovian signals on instrumental performance and refute the hypothesis that the nucleus accumbens is part of the neural circuitry by which incentive value is attached to the representations of instrumental outcomes.
引用
收藏
页码:50 / 68
页数:19
相关论文
共 76 条
[1]   VARIATIONS IN THE SENSITIVITY OF INSTRUMENTAL RESPONDING TO REINFORCER DEVALUATION [J].
ADAMS, CD .
QUARTERLY JOURNAL OF EXPERIMENTAL PSYCHOLOGY SECTION B-COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY, 1982, 34 (MAY) :77-98
[2]   THE EFFECTS OF IBOTENIC ACID LESIONS OF THE NUCLEUS ACCUMBENS ON SPATIAL-LEARNING AND EXTINCTION IN THE RAT [J].
ANNETT, LE ;
MCGREGOR, A ;
ROBBINS, TW .
BEHAVIOURAL BRAIN RESEARCH, 1989, 31 (03) :231-242
[3]  
BAKSHI VP, 1991, PSYCHOBIOLOGY, V19, P223
[4]   EFFECTS OF IBOTENIC ACID LESIONS OF THE NUCLEUS-ACCUMBENS ON INSTRUMENTAL ACTION [J].
BALLEINE, B ;
KILLCROSS, S .
BEHAVIOURAL BRAIN RESEARCH, 1994, 65 (02) :181-193
[5]   THE ACQUISITION OF SELF-STIMULATION OF THE MEDIAL PREFRONTAL CORTEX FOLLOWING EXPOSURE TO ESCAPABLE OR INESCAPABLE FOOTSHOCK [J].
BALLEINE, B .
BEHAVIOURAL BRAIN RESEARCH, 1991, 43 (02) :167-174
[6]  
BALLEINE B, 1994, Q J EXP PSYCHOL-B, V47, P211
[7]  
Balleine BW, 2001, HANDBOOK OF CONTEMPORARY LEARNING THEORIES, P307
[8]   What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? [J].
Berridge, KC ;
Robinson, TE .
BRAIN RESEARCH REVIEWS, 1998, 28 (03) :309-369
[9]   TASTE REACTIVITY ANALYSIS OF 6-HYDROXYDOPAMINE-INDUCED APHAGIA - IMPLICATIONS FOR AROUSAL AND ANHEDONIA HYPOTHESES OF DOPAMINE FUNCTION [J].
BERRIDGE, KC ;
VENIER, IL ;
ROBINSON, TE .
BEHAVIORAL NEUROSCIENCE, 1989, 103 (01) :36-45
[10]   WHAT PSYCHOLOGICAL PROCESS MEDIATES FEEDING EVOKED BY ELECTRICAL-STIMULATION OF THE LATERAL HYPOTHALAMUS [J].
BERRIDGE, KC ;
VALENSTEIN, ES .
BEHAVIORAL NEUROSCIENCE, 1991, 105 (01) :3-14