2-Ethyl-3-hydroxy-6-methylpyridine nitroxy succinate as a multifunctional hybrid structure

被引：3

作者：

Bogatyrenko, T. N. ^{[1
]}

Kuropteva, Z., V ^{[2
]}

Baider, L. M. ^{[2
]}

Bogatyrenko, V. R. ^{[1
]}

Mishchenko, D., V ^{[1
,3
]}

机构：

[1] Russian Acad Sci, Inst Problems Chem Phys, 1 Prosp Akad Semenova, Chernogolovka 142432, Moscow Region, Russia

[2] Russian Acad Sci, NM Emanuel Inst Biochem Phys, 4 Ul Kosygina, Moscow 119334, Russia

[3] Moscow Reg State Univ Chernogolovka, Med Chem Res & Educ Ctr, 24 Ul Very Voloshinoi, Mytishchi 141014, Moscow Region, Russia

来源：

RUSSIAN CHEMICAL BULLETIN | 2020年 / 69卷 / 10期

关键词：

nitric oxide; EPR spectroscopy; antioxidants; mitochondrial iron-sulfur clusters; HEMOGLOBIN;

D O I：

10.1007/s11172-020-2991-4

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The effect of 2-ethyl-3-hydroxy-6-methylpyridine nitroxy succinate (1) on heart, brain, and liver tissues of experimental animals (C57/b1 mice) was studied by EPR. It was shown that compound 1, like nicorandil, increases the nitric oxide production in cells and, like mexidol, protects iron-sulfur clusters of the mitochondrial respiratory chain in heart, brain, and liver tissues of animals against oxidative damage. Experimental evidence was obtained that under oxidative conditions, mitochondrial iron-sulfur clusters are maintained in the reduced functional state due to the presence of succinate (as nitroxy succinic acid), as a metabolite of the tricarboxylic acid cycle, in compound 1.

引用

页码：1999 / 2003

页数：5

共 19 条

[1]

[Anonymous], 2007, ROSS KHIM ZH ROSS KH

[2]

Baider L M, 2009, VOPROSY BIOL MED FAR, V3, P44

[3] Effect of mexidol and nitroglycerine on iron-sulfur centers, cytochrome P-450, and nitric oxide formation in liver tissue of experimental animals [J].