Analysis of the androgen receptor-regulated lncRNA landscape identifies a role for ARLNC1 in prostate cancer progression

被引：188

作者：

Zhang, Yajia ^{[1
,2
,3
,4
]}

Pitchiaya, Sethuramasundaram ^{[1
,2
]}

Cieslik, Marcin ^{[1
,2
]}

Niknafs, Yashar S. ^{[1
,5
]}

Tien, Jean C. -Y. ^{[1
,2
]}

Hosono, Yasuyuki ^{[1
]}

Iyer, Matthew K. ^{[1
,4
]}

Yazdani, Sahr ^{[1
]}

Subramaniam, Shruthi ^{[1
]}

Shukla, Sudhanshu K. ^{[1
,21
]}

Jiang, Xia ^{[1
]}

Wang, Lisha ^{[1
]}

Liu, Tzu-Ying ^{[6
]}

Uhl, Michael ^{[7
,8
]}

Gawronski, Alexander R. ^{[9
]}

Qiao, Yuanyuan ^{[1
,2
,10
]}

Xiao, Lanbo ^{[1
]}

Dhanasekaran, Saravana M. ^{[1
,2
]}

Juckette, Kristin M. ^{[1
]}

Kunju, Lakshmi P. ^{[1
,2
,10
]}

Cao, Xuhong ^{[1
,11
]}

Patel, Utsav ^{[12
]}

Batish, Mona ^{[12
,13
]}

Shukla, Girish C. ^{[14
]}

Paulsen, Michelle T. ^{[10
,15
]}

Ljungman, Mats ^{[10
,15
]}

Jiang, Hui ^{[6
,10
]}

Mehra, Rohit ^{[2
,10
,16
]}

Backofen, Rolf ^{[7
,8
]}

Sahinalp, Cenk S. ^{[17
,18
]}

Freier, Susan M. ^{[19
]}

Watt, Andrew T. ^{[19
]}

Guo, Shuling ^{[19
]}

Wei, John T. ^{[16
]}

Feng, Felix Y. ^{[1
,10
,15
,20
,22
,23
,24
]}

Malik, Rohit ^{[1
,25
]}

Chinnaiyan, Arul M. ^{[1
,2
,4
,5
,10
,11
,16
]}

机构：

[1] Univ Michigan, Michigan Ctr Translat Pathol, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Pathol, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Mol & Cellular Pathol Program, Ann Arbor, MI 48109 USA

[4] Dept Computat Med & Bioinformat, Ann Arbor, MI 48109 USA

[5] Univ Michigan, Dept Cellular & Mol Biol, Ann Arbor, MI 48109 USA

[6] Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA

[7] Univ Freiburg, Dept Comp Sci, Freiburg, Germany

[8] Univ Freiburg, Ctr Biol Signaling Studies BIOSS, Freiburg, Germany

[9] Simon Fraser Univ, Sch Comp Sci, Burnaby, BC, Canada

[10] Univ Michigan, Rogel Canc Ctr, Ann Arbor, MI 48109 USA

[11] Univ Michigan, Howard Hughes Med Inst, Ann Arbor, MI 48109 USA

[12] Rutgers State Univ, New Jersey Med Sch, Newark, NJ USA

[13] Univ Delaware, Dept Med Lab Sci, Newark, DE USA

[14] Cleveland State Univ, Ctr Gene Regulat Hlth & Dis, Dept Biol Geol & Environm Sci, Cleveland, OH 44115 USA

[15] Univ Michigan, Dept Radiat Oncol, Ann Arbor, MI 48109 USA

[16] Univ Michigan, Dept Urol, Ann Arbor, MI 48109 USA

[17] Indiana Univ, Sch Informat & Comp, Bloomington, IN USA

[18] Vancouver Prostate Ctr, Vancouver, BC, Canada

[19] Ionis Pharmaceut, Carlsbad, CA USA

[20] Univ Michigan, Breast Oncol Program, Ann Arbor, MI 48109 USA

[21] Indian Inst Technol Dharwad, Dept Biosci & Bioengn, Dharwad, Karnataka, India

[22] Univ Calif San Francisco, Dept Radiat Oncol, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA USA

[23] Univ Calif San Francisco, Dept Urol, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA USA

[24] Univ Calif San Francisco, Dept Med, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA USA

[25] Bristol Myers Squibb, Princeton, NJ USA

来源：

NATURE GENETICS | 2018年 / 50卷 / 06期

关键词：

LONG NONCODING RNA; GENE-EXPRESSION DATA; MESSENGER-RNA; ANTISENSE OLIGONUCLEOTIDES; DEPRIVATION THERAPY; HUMAN TRANSCRIPTOME; ANTITUMOR-ACTIVITY; INCREASED SURVIVAL; ABIRATERONE; CASTRATION;

D O I：

10.1038/s41588-018-0120-1

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The androgen receptor (AR) plays a critical role in the development of the normal prostate as well as prostate cancer. Using an integrative transcriptomic analysis of prostate cancer cell lines and tissues, we identified ARLNC1 (AR-regulated long noncoding RNA 1) as an important long noncoding RNA that is strongly associated with AR signaling in prostate cancer progression. Not only was ARLNC1 induced by the AR protein, but ARLNC1 stabilized the AR transcript via RNA-RNA interaction. ARLNC1 knockdown suppressed AR expression, global AR signaling and prostate cancer growth in vitro and in vivo. Taken together, these data support a role for ARLNC1 in maintaining a positive feedback loop that potentiates AR signaling during prostate cancer progression and identify ARLNC1 as a novel therapeutic target.

引用

页码：814 / +

页数：17

共 71 条

[1] The Molecular Taxonomy of Primary Prostate Cancer [J].

Abeshouse, Adam ;

Ahn, Jaeil ;

Akbani, Rehan ;

Ally, Adrian ;

Amin, Samirkumar ;

Andry, Christopher D. ;

Annala, Matti ;

Aprikian, Armen ;

Armenia, Joshua ;

Arora, Arshi ;

Auman, J. Todd ;

Balasundaram, Miruna ;

Balu, Saianand ;

Barbieri, Christopher E. ;

Bauer, Thomas ;

Benz, Christopher C. ;

Bergeron, Alain ;

Beroukhim, Rameen ;

Berrios, Mario ;

Bivol, Adrian ;

Bodenheimer, Tom ;

Boice, Lori ;

Bootwalla, Moiz S. ;

dos Reis, Rodolfo Borges ;

Boutros, Paul C. ;

Bowen, Jay ;

Bowlby, Reanne ;

Boyd, Jeffrey ;

Bradley, Robert K. ;

Breggia, Anne ;

Brimo, Fadi ;

Bristow, Christopher A. ;

Brooks, Denise ;

Broom, Bradley M. ;

Bryce, Alan H. ;

Bubley, Glenn ;

Burks, Eric ;

Butterfield, Yaron S. N. ;

Button, Michael ;

Canes, David ;

Carlotti, Carlos G. ;

Carlsen, Rebecca ;

Carmel, Michel ;

Carroll, Peter R. ;

Carter, Scott L. ;

Cartun, Richard ;

Carver, Brett S. ;

Chan, June M. ;

Chang, Matthew T. ;

Chen, Yu .

CELL, 2015, 163 (04) :1011-1025

[2] HTSeq-a Python']Python framework to work with high-throughput sequencing data [J].

Anders, Simon ;

Pyl, Paul Theodor ;

Huber, Wolfgang .

BIOINFORMATICS, 2015, 31 (02) :166-169

[3]

[Anonymous], 1967, SURG GYNECOL OBSTET

[4] AR-V7 and Resistance to Enzalutamide and Abiraterone in Prostate Cancer [J].

Antonarakis, Emmanuel S. ;

Lu, Changxue ;

Wang, Hao ;

Luber, Brandon ;

Nakazawa, Mary ;

Roeser, Jeffrey C. ;

Chen, Yan ;

Mohammad, Tabrez A. ;

Chen, Yidong ;

Fedor, Helen L. ;

Lotan, Tamara L. ;

Zheng, Qizhi ;

De Marzo, Angelo M. ;

Isaacs, John T. ;

Isaacs, William B. ;

Nadal, Rosa ;

Paller, Channing J. ;

Denmeade, Samuel R. ;

Carducci, Michael A. ;

Eisenberger, Mario A. ;

Luo, Jun .

NEW ENGLAND JOURNAL OF MEDICINE, 2014, 371 (11) :1028-1038

[5] The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans [J].

Ardlie, Kristin G. ;

DeLuca, David S. ;

Segre, Ayellet V. ;

Sullivan, Timothy J. ;

Young, Taylor R. ;

Gelfand, Ellen T. ;

Trowbridge, Casandra A. ;

Maller, Julian B. ;

Tukiainen, Taru ;

Lek, Monkol ;

Ward, Lucas D. ;

Kheradpour, Pouya ;

Iriarte, Benjamin ;

Meng, Yan ;

Palmer, Cameron D. ;

Esko, Tonu ;

Winckler, Wendy ;

Hirschhorn, Joel N. ;

Kellis, Manolis ;

MacArthur, Daniel G. ;

Getz, Gad ;

Shabalin, Andrey A. ;

Li, Gen ;

Zhou, Yi-Hui ;

Nobel, Andrew B. ;

Rusyn, Ivan ;

Wright, Fred A. ;

Lappalainen, Tuuli ;

Ferreira, Pedro G. ;

Ongen, Halit ;

Rivas, Manuel A. ;

Battle, Alexis ;

Mostafavi, Sara ;

Monlong, Jean ;

Sammeth, Michael ;

Mele, Marta ;

Reverter, Ferran ;

Goldmann, Jakob M. ;

Koller, Daphne ;

Guigo, Roderic ;

McCarthy, Mark I. ;

Dermitzakis, Emmanouil T. ;

Gamazon, Eric R. ;

Im, Hae Kyung ;

Konkashbaev, Anuar ;

Nicolae, Dan L. ;

Cox, Nancy J. ;

Flutre, Timothee ;

Wen, Xiaoquan ;

Stephens, Matthew .

SCIENCE, 2015, 348 (6235) :648-660

[6] Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer [J].

Asangani, Irfan A. ;

Dommeti, Vijaya L. ;

Wang, Xiaoju ;

Malik, Rohit ;

Cieslik, Marcin ;

Yang, Rendong ;

Escara-Wilke, June ;

Wilder-Romans, Kari ;

Dhanireddy, Sudheer ;

Engelke, Carl ;

Iyer, Mathew K. ;

Jing, Xiaojun ;

Wu, Yi-Mi ;

Cao, Xuhong ;

Qin, Zhaohui S. ;

Wang, Shaomeng ;

Feng, Felix Y. ;

Chinnaiyan, Arul M. .

NATURE, 2014, 510 (7504) :278-+

[7] New Strategies in Metastatic Prostate Cancer: Targeting the Androgen Receptor Signaling Pathway [J].

Attard, Gerhardt ;

Richards, Juliet ;

de Bono, Johann S. .

CLINICAL CANCER RESEARCH, 2011, 17 (07) :1649-1657

[8] MEME SUITE: tools for motif discovery and searching [J].

Bailey, Timothy L. ;

Boden, Mikael ;

Buske, Fabian A. ;

Frith, Martin ;

Grant, Charles E. ;

Clementi, Luca ;

Ren, Jingyuan ;

Li, Wilfred W. ;

Noble, William S. .

NUCLEIC ACIDS RESEARCH, 2009, 37 :W202-W208

[9] Androgen Receptor Splice Variants Activate Androgen Receptor Target Genes and Support Aberrant Prostate Cancer Cell Growth Independent of Canonical Androgen Receptor Nuclear Localization Signal [J].

Chan, Siu Chiu ;

Li, Yingming ;

Dehm, Scott M. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (23) :19736-19749

[10] Targeting the androgen receptor pathway in prostate cancer [J].

Chen, Yu ;

Sawyers, Charles L. ;

Scher, Howard I. .

CURRENT OPINION IN PHARMACOLOGY, 2008, 8 (04) :440-448

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