Linkage confirms canine pkd1 orthologue as a candidate for bull terrier polycystic kidney disease

被引：6
作者：
O'Leary, C. A. [1 ]
Duffy, D. [2 ]
Biros, I. [3 ]
Corley, S. [3 ]
机构：
[1] Univ Queensland, Sch Vet Sci, Brisbane, Qld 4072, Australia
[2] Queensland Inst Med Res, Genet Epidemiol Lab, Brisbane, Qld 4029, Australia
[3] Univ Queensland, Australian Equine Genet Res Ctr, Brisbane, Qld 4072, Australia
来源：
ANIMAL GENETICS | 2009年 / 40卷 / 04期
关键词：
dog; linkage analysis; PKD1; polycystic kidney disease; RADIATION HYBRID; GENOME; MAP;
D O I：
10.1111/j.1365-2052.2009.01863.x
中图分类号：
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号：
0905 ;
摘要：
P>Bull terrier polycystic kidney disease (BTPKD) is a Mendelian disorder with many features reminiscent of human autosomal dominant polycystic disease, the latter disease being due to mutations at PKD1 and PKD2 loci. We investigated the role of the canine pkd1 orthologue in BTPKD via linkage analysis of a large kindred in which the disorder is segregating. Twelve microsatellite markers around the canine pkd1 locus (CFA6) were amplified from the genomic DNA of 20 affected and 16 unaffected bull terriers. An additional 28 affected dogs were genotyped at five key microsatellites. A highly significant multi-point LOD score that peaked over the canine pkd1 locus was observed (LOD = 6.59, best two-point LOD score LOD = 6.02), implicating this as the BTPKD locus.
引用
收藏
页码：543 / 546
页数：4
相关论文
共 16 条
  • [1] [Anonymous], 1998, Genetics and Analysis of Quantitative Traits (Sinauer)
  • [2] Chromosome-specific single-locus FISH probes allow anchorage of an 1800-marker integrated radiation-hybrid/linkage map of the domestic dog genome to all chromosomes
    Breen, M
    Jouquand, S
    Renier, C
    Mellersh, CS
    Hitte, C
    Holmes, NG
    Chéron, A
    Suter, N
    Vignaux, F
    Bristow, AE
    Priat, C
    McCann, E
    André, C
    Boundy, S
    Gitsham, P
    Thomas, R
    Bridge, WL
    Spriggs, HF
    Ryder, EJ
    Curson, A
    Sampson, J
    Ostrander, EA
    Binns, MM
    Galibert, F
    [J]. GENOME RESEARCH, 2001, 11 (10) : 1784 - 1795
  • [3] DALGAARD O Z, 1957, Acta Med Scand Suppl, V328, P1
  • [4] DUFFY D, 2005, SIB PAIR COMPUTER PR
  • [5] Relationship estimation in affected rib pair analysis of late-onset diseases
    Goring, HHH
    Ott, J
    [J]. EUROPEAN JOURNAL OF HUMAN GENETICS, 1997, 5 (02) : 69 - 77
  • [6] HASSTEDT SJ, 2002, PEDIGREE ANAL PACKAG
  • [7] ECHOCARDIOGRAPHIC FINDINGS IN AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY-DISEASE
    HOSSACK, KF
    LEDDY, CL
    JOHNSON, AM
    SCHRIER, RW
    GABOW, PA
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1988, 319 (14) : 907 - 912
  • [8] Chromosomal assignment of canine TSC2, PKD1 and CLN3 genes by radiation hybrid- and linkage analyses
    Jónasdóttir, TJ
    Mellersh, CS
    Moe, L
    Vignaux, F
    Ostrander, EA
    Lingaas, F
    [J]. ANIMAL GENETICS, 2000, 31 (02) : 123 - 126
  • [9] An integrated linkage-radiation hybrid map of the canine genome
    Mellersh, CS
    Hitte, C
    Richman, M
    Vignaux, F
    Priat, C
    Jouquand, S
    Werner, P
    André, C
    DeRose, S
    Patterson, DF
    Ostrander, EA
    Galibert, F
    [J]. MAMMALIAN GENOME, 2000, 11 (02) : 120 - 130
  • [10] A SIMPLE SALTING OUT PROCEDURE FOR EXTRACTING DNA FROM HUMAN NUCLEATED CELLS
    MILLER, SA
    DYKES, DD
    POLESKY, HF
    [J]. NUCLEIC ACIDS RESEARCH, 1988, 16 (03) : 1215 - 1215
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