Protective Effect of Caffeic Acid against Alzheimer's Disease Pathogenesis via Modulating Cerebral Insulin Signaling, β-Amyloid Accumulation, and Synaptic Plasticity in Hyperinsulinemic Rats

被引：69

作者：

Chang, Wenchang ^{[1
]}

Huang, Dawei ^{[2
]}

Lo, Y. Martin ^{[3
]}

Tee, Qinqiao ^{[4
]}

Kuo, Poling ^{[4
]}

Wu, James Swibea ^{[5
]}

Huang, Wenchung ^{[6
]}

Shen, Szuchuan ^{[4
]}

机构：

[1] Natl Chiayi Univ, Dept Food Sci, 300 Syuefu Rd, Chiayi 60004, Taiwan

[2] Southern Taiwan Univ Sci & Technol, Dept Biotechnol & Food Technol, 1 Nan Tai St, Tainan 710, Taiwan

[3] Shenzhen Univ, Inst Adv Study, 3688 Nanhai Blvd, Shenzhen 518060, Peoples R China

[4] Natl Taiwan Normal Univ, Grad Program Nutr Sci, 162,Sec 1,Heping East Rd, Taipei 10610, Taiwan

[5] Natl Taiwan Univ, Grad Inst Food Sci & Technol, POB 23-14, Taipei 10672, Taiwan

[6] Chang Gung Univ Sci & Technol, Grad Inst Hlth Ind Technol, 261 Wenhua First Rd, Taoyuan 33303, Taiwan

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2019年 / 67卷 / 27期

关键词：

caffeic acid; hyperinsulinemic; Alzheimer's disease; cerebral carbohydrate metabolism; NEUROTROPHIC FACTORS; GLUCOSE-METABOLISM; OXIDATIVE STRESS; DIETARY-FAT; MOUSE MODEL; BRAIN; TAU; MICE; SUPEROXIDE; RESISTANCE;

D O I：

10.1021/acs.jafc.9b02078

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

This study investigated the alleviative effect of caffeic acid (CA) on Alzheimer's disease (AD) pathogenesis and associated mechanisms in high-fat (HF) diet-induced hyperinsulinemic rats. The results of a Morris water maze indicated that, by administrating CA (30 mg/kg b.w./day) for 30 weeks, the memory and learning impairments in HF-induced hyperinsulinemic rats were significantly ameliorated. CA also enhanced superoxide dismutase and glutathione free radical scavenger activity in hyperinsulinemic rats. The Western blot data further confirmed that protein expressions of phosphorylated-glycogen synthase kinase 3 beta (GSK3 beta) were significantly increased, whereas the expression of phosphorylated-tau protein decreased in the hippocampus of rats administered with CA in comparison with the HF group. Moreover, the expression of amyloid precursor protein (APP) and beta-site APP cleaving enzyme were attenuated, subsequently lowering the level of beta-amyloid 1-42 (A beta 1-42) in the hippocampus of CA-treated hyperinsulinemic rats. CA also significantly increased the expression of synaptic proteins in HF rats.

引用

页码：7684 / 7693

页数：10

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