Virus-like nanoparticles (VLPs) based technology in the development of breast cancer ?vaccines?

被引：8

作者：

Arab, Atefeh ^{[1
]}

Nikpoor, Amin Reza ^{[2
]}

Asadi, Peyman ^{[3
]}

Iraei, Reza ^{[4
]}

Yazdian-Robati, Rezvan ^{[5
]}

Sheikh, Afsana ^{[6
]}

Kesharwani, Prashant ^{[6
,7
]}

机构：

[1] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmaceut Biotechnol, Mashhad, Iran

[2] Hormozgan Univ Med Sci, Hormozgan Hlth Inst, Mol Med Res Ctr, Bandar Abbas, Iran

[3] Mazandaran Univ Med Sci, Sch Adv Technol Med, Dept Med Nanotechnol, Sari, Iran

[4] Mazandaran Univ Med Sci, Fac Med, Dept Biochem & Genet, Sari, Iran

[5] Mazandaran Univ Med Sci, Fac Med, Mol & Cell Biol Res Ctr, Sari, Iran

[6] Jamia Hamdard, Sch Pharmaceut Educ & Res, Dept Pharmaceut, New Delhi 110062, India

[7] Saveetha Inst Med & Tech Sci, Saveetha Dent Coll, Ctr Transdisciplinary Res, Dept Pharmacol, Chennai, India

来源：

PROCESS BIOCHEMISTRY | 2022年 / 123卷

关键词：

Virus -like particle; Vaccine; Breast cancer; Humoral immunity; Cellular immunity; Complement system; TUMOR-ASSOCIATED ANTIGENS; HUMORAL IMMUNITY; MOSAIC-VIRUS; PARTICLES; CELLS; DELIVERY; MUC1; IMMUNOGENICITY; CANDIDATE; RESPONSES;

D O I：

10.1016/j.procbio.2022.10.020

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Virus-like nanoparticles (VLPs) resemble structures of viruses that are devoid of the viral genome, which are widely exerted in vaccine designs, especially cancer vaccines. These particles can trigger both humoral and cellular immunity due to their particular nature and repetitive structure. The average diameter size of most VLPs is in the range of 20-200 nm, which provides easy draining into lymphatic vessels for stimulating the immune system without requiring any adjuvants. Many investigations focused on the task of designing vaccines based on VLPs to improve their efficacy for prophylactic and therapeutic applications throughout cancer treatments. In this review, we discussed the recent developments of VLPs based technology in regard to breast cancer.

引用

页码：44 / 51

页数：8

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