Development of a hybrid quantum chemical and molecular mechanics method with application to solvent effects on the electronic spectra of uracil and uracil derivatives

被引:54
作者
Broo, A [1 ]
Pearl, G [1 ]
Zerner, MC [1 ]
机构
[1] UNIV FLORIDA, QUANTUM THEORY PROJECT, GAINESVILLE, FL 32611 USA
关键词
D O I
10.1021/jp9629699
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
A method for molecular dynamics (MD), Monte Carlo (MC), and energy minimization simulation utilizing a Hamiltonian that is divided into two parts is described. One part is treated with a quantum mechanical Hamiltonian, typically a small part of the simulated system that comprises the chromophore. The other part is treated with a classical mechanical Hamiltonian. This partitioning of the system allows us to simulate, for example, not only electronic spectroscopy but also chemical reactions when a bond is broken or to explore the excited state potential energy surface. The particular choice of the quantum mechanical Hamiltonian, the intermediate neglecting of differential overlap (INDO) model Hamiltonian, also offers the possibility of simulating systems that contain a transition metal, which only rarely have been accessible with traditional MD and MC methods. Test calculations on small systems are presented together with an investigation of the photophysics of uracil and 1,3-dimethyluracil.
引用
收藏
页码:2478 / 2488
页数:11
相关论文
共 49 条
[1]   THEORETICAL-STUDY OF ELECTRONIC-SPECTRA AND PHOTOPHYSICS OF URACIL DERIVATIVES [J].
BARALDI, I ;
BRUNI, MC ;
COSTI, MP ;
PECORARI, P .
PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1990, 52 (02) :361-374
[2]   PHOTOPHYSICAL PROPERTIES OF NUCLEIC-ACID COMPONENTS .1. PYRIMIDINES - THYMINE, URACIL, N,N-DIMETHYL DERIVATIVES AND THYMIDINE [J].
BECKER, RS ;
KOGAN, G .
PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1980, 31 (01) :5-13
[3]   SOME MULTISTEP METHODS FOR USE IN MOLECULAR-DYNAMICS CALCULATIONS [J].
BEEMAN, D .
JOURNAL OF COMPUTATIONAL PHYSICS, 1976, 20 (02) :130-139
[4]  
Berendsen H. J., 1981, Intermolecular Forces, DOI [10.1007/978-94-015-7658, DOI 10.1007/978-94-015-7658, DOI 10.1007/978-94-015-7658-1_21]
[5]   MOLECULAR-DYNAMICS WITH COUPLING TO AN EXTERNAL BATH [J].
BERENDSEN, HJC ;
POSTMA, JPM ;
VANGUNSTEREN, WF ;
DINOLA, A ;
HAAK, JR .
JOURNAL OF CHEMICAL PHYSICS, 1984, 81 (08) :3684-3690
[6]   THE DYNAMICS OF SOME METAL-ORGANIC AND ORGANIC-MOLECULES IN WATER SOLUTION STUDIED BY MOLECULAR MECHANICAL AND MOLECULAR DYNAMICAL METHODS [J].
BROO, A .
CHEMICAL PHYSICS, 1993, 174 (01) :127-139
[7]  
BROO A, UNPUB
[8]   AN EXTENDED SEMIEMPIRICAL MOLECULAR-ORBITAL STUDY OF THE PI-PI-STAR EXCITED-STATES OF NUCLEIC-ACID BASES [J].
CALLIS, PR .
PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1986, 44 (03) :315-332
[9]   ELECTRONIC STATES AND LUMINESCENCE OF NUCLEIC-ACID SYSTEMS [J].
CALLIS, PR .
ANNUAL REVIEW OF PHYSICAL CHEMISTRY, 1983, 34 :329-357
[10]   Solvent effects on the potential energy surface of the 1:1 complex of water and formamide: Application of the polarizable continuum model to the study of nonadditive effects [J].
Contador, JC ;
Sanchez, ML ;
Aguilar, MA ;
delValle, FJO .
JOURNAL OF CHEMICAL PHYSICS, 1996, 104 (14) :5539-5546