Genetic variations in genes of the stress response pathway are associated with prolonged abstinence from heroin

被引：12

作者：

Levran, Orna ^{[1
]}

Peles, Einat ^{[2
,3
]}

Randesi, Matthew ^{[1
]}

da Rosa, Joel Correa ^{[4
,5
]}

Shen, Pei-Hong ^{[6
]}

Rotrosen, John ^{[7
]}

Adelson, Miriam ^{[2
,8
]}

Kreek, Mary Jeanne ^{[1
]}

机构：

[1] Rockefeller Univ, Lab Biol Addict Dis, 1230 York Ave,Box 171, New York, NY 10065 USA

[2] Tel Aviv Elias Sourasky Med Ctr, Dr Miriam & Sheldon G Adelson Clin Drug Abuse Tre, 1 Henrietta Szold St, IL-64924 Tel Aviv, Israel

[3] Tel Aviv Univ, Sackler Fac Med, IL-69978 Ramat Aviv, Israel

[4] Rockefeller Univ, Ctr Clin & Translat Sci, New York, NY 10065 USA

[5] Icahn Sch Med Mt Sinai, Dept Populat Hlth Sci & Policy, New York, NY 10029 USA

[6] NIAAA, Lab Neurogenet, NIH, Rockville, MD 20852 USA

[7] NYU, Sch Med, New York, NY 10016 USA

[8] Dr Miriam & Sheldon G Adelson Clin Drug Abuse Tre, Las Vegas, NV 89169 USA

来源：

PHARMACOGENOMICS | 2018年 / 19卷 / 04期

关键词：

abstinence; CRHBP; glucocorticoid receptor; HPA axis; NPY1R; NPY5R; stress resilience; SUBSTANCE USE DISORDERS; GLUCOCORTICOID-RECEPTOR; NEUROPEPTIDE-Y; CANDIDATE GENES; PSYCHIATRIC-DISORDERS; ALCOHOL-DEPENDENCE; COCAINE ADDICTION; CHILDHOOD TRAUMA; DRUG-DEPENDENCE; FACTOR SYSTEM;

D O I：

10.2217/pgs-2017-0179

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Aim: This study assesses whether genetic variants in stress-related genes are associated with prolonged abstinence from heroin in subjects that are not in long-term methadone treatment. Methods: Frequencies of 117 polymorphisms in 30 genes were compared between subjects with history of heroin addiction, either without agonist treatment (n = 129) or in methadone maintenance treatment (n = 923). Results: SNP rs1500 downstream of CRHBP and an interaction of SNPs rs10482672 (NR3C1) and rs4234955 (NPY1R/NPY5R) were significantly associated with prolonged abstinence without agonist treatment. Conclusion: This study suggests that variability in stress-related genes may contribute to the ability of certain subjects to remain in prolonged abstinence from heroin, possibly due to higher resilience to stress.

引用

页码：333 / 341

页数：9

共 53 条

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