Antimalarial compounds from Parinari capensis

被引：33
作者：
Uys, ACU
Malan, SF
van Dyk, S
van Zyl, RL
机构：
[1] Potchefstroom Univ Christian Higher Educ, Sch Pharm, ZA-2520 Potchefstroom, South Africa
[2] Univ Witwatersrand, Fac Hlth Sci, Dept Pharm & Pharmacol, ZA-2193 Parktown, South Africa
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 16期
关键词：
D O I：
10.1016/S0960-894X(02)00350-5
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The antimalarial activity of the raw petroleum ether and dichloromethane extracts of the stems of Parinari capensis (Chrysobalanceae) was determined. Phytochemical investigation of these extracts led to the isolation of three diterpene lactones that possess antimalarial activity with IC50 Values of 0.54, 0.67, and 1.57 mug/mL. Although their antimalarial activity is promising, the toxicity profiles of these diterpene lactones prevent further biological evaluation. They could however be used effectively as lead compounds in the synthesis of novel antimalarial agents. (C) 2002 Elsevier Science Ltd. All rights reserved.
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页码：2167 / 2169
页数：3
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