Prevalence of opportunistic invasive aspergillosis in COVID-19 patients with severe pneumonia

被引:61
作者
Segrelles-Calvo, Gonzalo [1 ,2 ]
Araujo, Glauber R. S. [3 ]
Llopis-Pastor, Estefania [1 ]
Carrillo, Javier [1 ,4 ]
Hernandez-Hernandez, Marta [1 ]
Rey, Laura [1 ]
Rodriguez Melean, Nestor [1 ]
Escribano, Ines [1 ,2 ]
Anton, Esther [1 ]
Zamarro, Celia [1 ]
Garcia-Salmones, Mercedes [1 ,4 ]
Frases, Susana [3 ]
机构
[1] Hosp Univ Rey Juan Carlos, Serv Neumol, Madrid, Spain
[2] Fdn Jimenez Diaz, Inst Invest Biomed, Madrid, Spain
[3] Univ Fed Rio Janeiro, Inst Biofis Carlos Chagas Filho, Lab Biofis Fungos, Cidade Univ, BR-21941902 Rio De Janeiro, RJ, Brazil
[4] Hosp Univ Infanta Elena, Serv Neumol, Madrid, Spain
关键词
COVID-19; invasive aspergillosis; lung disease; opportunistic mycosis; PULMONARY ASPERGILLOSIS; TOCILIZUMAB; INFECTIONS;
D O I
10.1111/myc.13219
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background: As the global coronavirus pandemic (COVID-19) spreads across the world, new clinical challenges emerge in the hospital landscape. Among these challenges, the increased risk of coinfections is a major threat to the patients. Although still in a low number, due to the short time of the pandemic, studies that identified a significant number of hospitalised patients with COVID-19 who developed secondary fungal infections that led to serious complications and even death have been published. Objectives: In this scenario, we aim to determine the prevalence of invasive fungal infections (IFIs) and describe possible associated risk factors in patients admitted due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Patients/Methods: We designed an open prospective observational study at the Rey Juan Carlos University Hospital (Mostoles, Spain), during the period from February 1 to April 30, 2020. Results: In this article, we reported seven patients with COVID-19-associated pulmonary aspergillosis (CAPA) who had a poor prognosis. Severely ill patients represent a high-risk group; therefore, we must actively investigate the possibility of aspergillosis in all of these patients. Larger cohort studies are needed to unravel the role of COVID-19 immunosuppressive therapy as a risk factor for aspergillosis. Conclusions: As the pandemic continues to spread across the world, further reports are needed to assess the frequency of emergent and highly resistant reemergent fungal infections during severe COVID-19. These coinfections are leading a significant number of patients with COVID-19 to death due to complications following the primary viral disease.
引用
收藏
页码:144 / 151
页数:8
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