Immunomodulatory effects of methoxylated flavonoids from two Chromolaena species:: Structure-activity relationships

被引：13

作者：

Taleb-Contini, S. H. ^{[1
]}

Kanashiro, A. ^{[1
]}

Kabeya, L. M. ^{[1
]}

Polizello, A. C. M. ^{[1
]}

Lucisano-Valim, Y. M. ^{[1
]}

Oliveira, D. C. R. ^{[1
]}

机构：

[1] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Quim & Fis, BR-14040903 Ribeirao Preto, Brazil

来源：

PHYTOTHERAPY RESEARCH | 2006年 / 20卷 / 07期

关键词：

flavonoids; neutrophil; luminol-dependent chemiluminescence; structure-activity relationship;

D O I：

10.1002/ptr.1908

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Excessive generation of reactive oxygen species (ROS) by polymorphonuclear leukocytes (PMNL) is involved in the pathology of many inflammatory diseases. Compounds isolated from natural sources with antioxidant activity can be helpful to inhibit and/or modulate the oxidative damage associated with PMNL-derived ROS. The present study investigated the relationship between the chemical structure of five methoxylated flavonoids, isolated from Chromolaena hirsuta and Chromolaena squalida, and their inhibitory activity on ROS generation by opsonized zymosan-stimulated PMNL. The antioxidant efficacy of the studied flavonoids, assessed by luminol-dependent chemiluminescence, was dependent on the position and number of methoxy and hydroxy groups. Copyright (c) 2006 John Wiley & Sons, Ltd.

引用

页码：573 / 575

页数：3

共 20 条

[1] Phagocytes and oxidative stress [J].

Babior, BM .

AMERICAN JOURNAL OF MEDICINE, 2000, 109 (01) :33-44

[2]

CHEUNG K, 1983, J IMMUNOL, V130, P2324

[3] Respiratory burst in human neutrophils [J].

Dahlgren, C ;

Karlsson, A .

JOURNAL OF IMMUNOLOGICAL METHODS, 1999, 232 (1-2) :3-14

[4] Evaluation of the total peroxyl radical-scavenging capacity of flavonoids:: Structure-activity relationships [J].

Dugas, AJ ;

Castañeda-Acosta, J ;

Bonin, GC ;

Price, KL ;

Fischer, NH ;

Winston, GW .

JOURNAL OF NATURAL PRODUCTS, 2000, 63 (03) :327-331

[5] Flavonoids as chemotaxonomic markers for Asteraceae [J].

Emerenciano, VP ;

Militao, JSLT ;

Campos, CC ;

Romoff, P ;

Kaplan, MAC ;

Zambon, M ;

Brant, AJC .

BIOCHEMICAL SYSTEMATICS AND ECOLOGY, 2001, 29 (09) :947-957

[6] Radical scavenger activity of phenylethanoid glycosides in FMLP stimulated human polymorphonuclear leukocytes:: Structure-activity relationships [J].

Heilmann, J ;

Calis, I ;

Kirmizibekmez, H ;

Schühly, W ;

Harput, S ;

Sticher, O .

PLANTA MEDICA, 2000, 66 (08) :746-748

[7] Chemistry of the Eupatoriinae [J].

Herz, W .

BIOCHEMICAL SYSTEMATICS AND ECOLOGY, 2001, 29 (11) :1115-1137

[8]

Kabeya Luciana M., 2002, Research Communications in Molecular Pathology and Pharmacology, V111, P103

[9] Inhibitory activity of flavonoids from Lychnophora sp on generation of reactive oxygen species by neutrophils upon stimulation by immune complexes [J].

Kanashiro, A ;

Kabeya, LM ;

Polizello, ACM ;

Lopes, NP ;

Lopes, JLC ;

Lucisano-Valim, YM .

PHYTOTHERAPY RESEARCH, 2004, 18 (01) :61-65

[10] Anti-inflammatory plant flavonoids and cellular action mechanisms [J].

Kim, HP ;

Son, KH ;

Chang, HW ;

Kang, SS .

JOURNAL OF PHARMACOLOGICAL SCIENCES, 2004, 96 (03) :229-245

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