Age at Menarche and Risks of All-Cause and Cardiovascular Death: A Systematic Review and Meta-Analysis

被引:199
作者
Charalampopoulos, Dimitrios [1 ]
McLoughlin, Andrew [1 ]
Elks, Cathy E. [2 ]
Ong, Ken K. [2 ]
机构
[1] Univ Cambridge, Sch Clin Med, Dept Publ Hlth & Primary Care, Cambridge CB2 0SR, England
[2] Univ Cambridge, MRC Epidemiol Unit, Cambridge CB2 0SR, England
基金
英国医学研究理事会;
关键词
cardiovascular disease; death rate; menarche; mortality; puberty; REPRODUCTIVE FACTORS; POSTMENOPAUSAL WOMEN; CIGARETTE-SMOKING; DISEASE MORTALITY; ASSOCIATION; MENOPAUSE; HISTORY; ADULTHOOD; SURVIVAL;
D O I
10.1093/aje/kwu113
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
We conducted a systematic review and meta-analysis to investigate the associations between menarcheal age and all-cause and cardiovascular death. Medline, Embase, Scopus, and Web of Knowledge were searched for articles published prior to March 2013 reporting on the associations between menarcheal age and death from all causes or from cardiovascular disease (total cardiovascular disease, ischemic heart disease (IHD), and stroke) in adult women. Nine articles were eligible for inclusion; these reported 5 estimates each for death from all causes and total cardiovascular death, 6 estimates for IHD, and 7 estimates for death from stroke. Our meta-analysis showed that each 1-year increase in age at menarche was associated with a 3% lower relative risk of death from all causes (pooled hazard ratio = 0.97, 95% confidence interval: 0.96, 0.98) with low heterogeneity (I-2 = 32.2%). Meta-analysis of 2 cohorts showed a higher risk of death from all causes for women who experienced early menarche (at < 12 years of age) versus "not early" menarche (at a parts per thousand yen12 years of age) (pooled hazard ratio = 1.23, 95% confidence interval: 1.10, 1.38; I-2 = 0%). An inverse association between age at menarche and death from IHD was observed only among nonsmoking populations or populations with low prevalence of smoking. We found no evidence of association between age at menarche and death from all cardiovascular diseases or stroke. Early menarche was consistently associated with higher risk of death from all causes. Further studies are needed to clarify the role of menarcheal age on cardiovascular outcomes and to investigate the potential modifying role of smoking.
引用
收藏
页码:29 / 40
页数:12
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