HLA-DRB1*15:01 and Epstein-Barr virus in a multiple sclerosis patient with psoriasis, nasopharyngeal and breast cancers. Lessons for possible hidden links for autoimmunity and cancer

被引:14
作者
Anagnostouli, Maria [1 ,2 ]
Anagnostoulis, Georgios [3 ]
Katsavos, Serafeim [1 ,2 ]
Panagiotou, Maria [1 ]
Kararizou, Evangelia [1 ]
Davaki, Panagiota [1 ]
机构
[1] Natl & Kapodistrian Univ, Sch Med, Aeginit Hosp, Dept Neurol, Athens 11528, Greece
[2] Aeginit Hosp, Dept Neurol, Immunogenet Lab, Athens, Greece
[3] Henry Dunant Hosp, Intens Care Unit, Athens, Greece
关键词
Multiple sclerosis; Psoriasis; Nasopharyngeal; Breast cancer; Human leucocyte; Epstein-Barr Virus; SMOOTH-MUSCLE TUMORS; IMMUNE-RESPONSE; T-CELLS; RISK; ASSOCIATION; CARCINOMA; DISEASES; SUSCEPTIBILITY; LYMPHOMA; FAMILIES;
D O I
10.1016/j.jns.2014.02.003
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: Multiple sclerosis (MS) patients have a low general cancer risk and cases of neoplastic comorbidity are attributed by many researchers in chance, or therapeutical side-effects. Human leucocyte antigen (HLA) class II allele DRB1*15:01 is considered the main genetic factor independently associated with increased susceptibility for MS in Caucasians. Epstein-Barr virus (EBV) has also been proven to be a core triggering factor in MS initiation and progress, mainly in HIA-DRB1*15:01 positive MS patients. Case report: We present an exceptional case of a Greek-origin woman, carrying a distinct immunogenetic profile (HLA-A*26:01-Cw*06:02-DRB1*15:01), which gradually developed psoriasis, nasopharyngeal carcinoma (NPC), MS, breast cancer, uterine leiomyoma and other neoplasms. Discussion: EBV plays a fundamental role in the pathogenesis of both autoimmunity (i.e. MS) and cancer (i.e. NPC). Our patient's immunogenetic profile included HLA alleles which are associated with psoriasis (Cw*06:02), NPC (A*26:01), MS (DRB1*15:01) and increased risk of MS, in patients carrying EBV (DRB1*15:01). We made a targeted review of the literature finding data supporting an EBV-HLA interaction mechanism behind our patient's unique combination of disorders, suggesting that beyond the standard role of each factor, their combination could act as the hidden link, in initiation or/and comorbidity of autoimmunity and cancer. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码:26 / 31
页数:6
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